Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study
Abstract Background Behaviors of substance dependence are common among patients with medication-overuse headache (MOH). Whether MOH, like other substance use disorders, is associated with an increased risk for suicide is unknown. Methods In this cross-sectional study, newly diagnosed chronic migrain...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-021-01248-0 |
| _version_ | 1818949348883431424 |
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| author | Yen-Feng Wang Chia-Chun Yu Ai Seon Kuan Shih-Pin Chen Shuu-Jiun Wang |
| author_facet | Yen-Feng Wang Chia-Chun Yu Ai Seon Kuan Shih-Pin Chen Shuu-Jiun Wang |
| author_sort | Yen-Feng Wang |
| collection | DOAJ |
| description | Abstract Background Behaviors of substance dependence are common among patients with medication-overuse headache (MOH). Whether MOH, like other substance use disorders, is associated with an increased risk for suicide is unknown. Methods In this cross-sectional study, newly diagnosed chronic migraine (CM) patients with or without coexisting MOH were enrolled prospectively. Headache diagnoses were made through face-to-face interviews by headache specialists, and a specifically designed questionnaire was used to collect demographics, headache profiles, Migraine Disability Assessment, Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index, etc. Suicidal ideation and prior suicide attempt were specifically questioned. Results In total, 603 CM patients (485F/118M, mean age 42.03 ± 12.18 years) were recruited, including 320 with MOH (257F/63M, mean age 42.8 ± 11.7 years) (53.1%), and 214 (35.5%) and 81 (13.4%) had suicidal ideation and prior suicide attempt, respectively. Among CM patients, the presence of MOH increased the risks of suicidal ideation (odds ratio [OR] = 1.75 [95% CI = 1.20–2.56], p = 0.004) and prior suicide attempt (OR = 1.88 [1.09–3.24], p = 0.024), after controlling for demographics, headache profile, disabilities, symptoms of anxiety and depression, and sleep quality. Conclusions In CM patients, MOH is associated with an increased risk for suicidal ideation and prior suicide attempt, which deserves attention for clinicians taking care of headache patients. However, further studies are needed to determine the causal relationship, as well as the underlying pathophysiology. |
| first_indexed | 2024-12-20T09:01:16Z |
| format | Article |
| id | doaj.art-1deb92e390a541d49e179c5ffdd91111 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-20T09:01:16Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-1deb92e390a541d49e179c5ffdd911112022-12-21T19:45:51ZengBMCThe Journal of Headache and Pain1129-23691129-23772021-05-012211810.1186/s10194-021-01248-0Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional studyYen-Feng Wang0Chia-Chun Yu1Ai Seon Kuan2Shih-Pin Chen3Shuu-Jiun Wang4Department of Neurology, Neurological Institute, Taipei Veterans General HospitalDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalSchool of Medicine, National Yang Ming Chiao Tung University College of MedicineDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalAbstract Background Behaviors of substance dependence are common among patients with medication-overuse headache (MOH). Whether MOH, like other substance use disorders, is associated with an increased risk for suicide is unknown. Methods In this cross-sectional study, newly diagnosed chronic migraine (CM) patients with or without coexisting MOH were enrolled prospectively. Headache diagnoses were made through face-to-face interviews by headache specialists, and a specifically designed questionnaire was used to collect demographics, headache profiles, Migraine Disability Assessment, Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index, etc. Suicidal ideation and prior suicide attempt were specifically questioned. Results In total, 603 CM patients (485F/118M, mean age 42.03 ± 12.18 years) were recruited, including 320 with MOH (257F/63M, mean age 42.8 ± 11.7 years) (53.1%), and 214 (35.5%) and 81 (13.4%) had suicidal ideation and prior suicide attempt, respectively. Among CM patients, the presence of MOH increased the risks of suicidal ideation (odds ratio [OR] = 1.75 [95% CI = 1.20–2.56], p = 0.004) and prior suicide attempt (OR = 1.88 [1.09–3.24], p = 0.024), after controlling for demographics, headache profile, disabilities, symptoms of anxiety and depression, and sleep quality. Conclusions In CM patients, MOH is associated with an increased risk for suicidal ideation and prior suicide attempt, which deserves attention for clinicians taking care of headache patients. However, further studies are needed to determine the causal relationship, as well as the underlying pathophysiology.https://doi.org/10.1186/s10194-021-01248-0MigraineSubstance dependenceMedication-overuse headacheSuicide |
| spellingShingle | Yen-Feng Wang Chia-Chun Yu Ai Seon Kuan Shih-Pin Chen Shuu-Jiun Wang Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study The Journal of Headache and Pain Migraine Substance dependence Medication-overuse headache Suicide |
| title | Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study |
| title_full | Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study |
| title_fullStr | Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study |
| title_full_unstemmed | Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study |
| title_short | Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study |
| title_sort | association between suicidal risks and medication overuse headache in chronic migraine a cross sectional study |
| topic | Migraine Substance dependence Medication-overuse headache Suicide |
| url | https://doi.org/10.1186/s10194-021-01248-0 |
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