Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo
Background Cobblestoning is the most common complication of minipunch grafting. Objective To assess the value of silicone gel application following minipunch grafting and the histopathological and immunohistochemical changes in cases with cobblestoning. Methods Minipunch grafting was performed in tw...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-01-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1751038 |
| _version_ | 1797683590029377536 |
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| author | Tag Anbar Talal Abd El Raheem Dalia Ahmed Bassiouny Marwa Mohamed Fawzy Zeinab El Maadawi Noha Farouk Mohamed Hassan |
| author_facet | Tag Anbar Talal Abd El Raheem Dalia Ahmed Bassiouny Marwa Mohamed Fawzy Zeinab El Maadawi Noha Farouk Mohamed Hassan |
| author_sort | Tag Anbar |
| collection | DOAJ |
| description | Background Cobblestoning is the most common complication of minipunch grafting. Objective To assess the value of silicone gel application following minipunch grafting and the histopathological and immunohistochemical changes in cases with cobblestoning. Methods Minipunch grafting was performed in two similar vitiligo lesions in 27 cases with stable vitiligo. After healing, silicone gel was applied twice daily on one lesion while zinc oxide ointment was applied to the other lesion serving as a control. Four biopsies were taken from each case; normal, vitiliginous skin before treatment and the two treated lesions 3 months after therapy, for histopathology and immunohistochemical staining for MMP9 & tenascin-C. Results Repigmentation occurred in 19 cases (70.7%). The number of lesions showing excellent and good response was significantly higher on the silicone gel side (p < .001). In 20 cases, cobblestoning either occurred or was absent on both sides. Histopathologically, cobblestoning was similar to hypertrophic scarring. Both markers were elevated after therapy on both sides with no significant difference in percentage change between lesions showing positive and negative cobblestoning. Conclusion Silicone gel application after minigrating improved the final response with no significant effect on the occurrence of cobblestoning. Cobblestoning resembled hypertrophic scarring histopathologically. |
| first_indexed | 2024-03-12T00:16:39Z |
| format | Article |
| id | doaj.art-1dec95e6afac400e9c999c8c87ebdea6 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:39Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-1dec95e6afac400e9c999c8c87ebdea62023-09-15T14:23:05ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-01-0133130631310.1080/09546634.2020.17510381751038Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligoTag Anbar0Talal Abd El Raheem1Dalia Ahmed Bassiouny2Marwa Mohamed Fawzy3Zeinab El Maadawi4Noha Farouk5Mohamed Hassan6Department of Dermatology, STDs and Andrology, Faculty of Medicine, Minia UniversityDepartment of Dermatology, STDs and Andrology, Faculty of Medicine, Fayoum UniversityDepartment of Dermatology, Cairo UniversityDepartment of Dermatology, Cairo UniversityDepartment of Histology, Faculty of Medicine, Cairo UniversityDepartment of Dermatology, STDs and Andrology, Helwan UniversityDepartment of Dermatology, STDs and Andrology, Faculty of Medicine, Fayoum UniversityBackground Cobblestoning is the most common complication of minipunch grafting. Objective To assess the value of silicone gel application following minipunch grafting and the histopathological and immunohistochemical changes in cases with cobblestoning. Methods Minipunch grafting was performed in two similar vitiligo lesions in 27 cases with stable vitiligo. After healing, silicone gel was applied twice daily on one lesion while zinc oxide ointment was applied to the other lesion serving as a control. Four biopsies were taken from each case; normal, vitiliginous skin before treatment and the two treated lesions 3 months after therapy, for histopathology and immunohistochemical staining for MMP9 & tenascin-C. Results Repigmentation occurred in 19 cases (70.7%). The number of lesions showing excellent and good response was significantly higher on the silicone gel side (p < .001). In 20 cases, cobblestoning either occurred or was absent on both sides. Histopathologically, cobblestoning was similar to hypertrophic scarring. Both markers were elevated after therapy on both sides with no significant difference in percentage change between lesions showing positive and negative cobblestoning. Conclusion Silicone gel application after minigrating improved the final response with no significant effect on the occurrence of cobblestoning. Cobblestoning resembled hypertrophic scarring histopathologically.http://dx.doi.org/10.1080/09546634.2020.1751038non segmental vitiligommp 9tenascinsurgical therapy in vitiligonb-uvb |
| spellingShingle | Tag Anbar Talal Abd El Raheem Dalia Ahmed Bassiouny Marwa Mohamed Fawzy Zeinab El Maadawi Noha Farouk Mohamed Hassan Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo Journal of Dermatological Treatment non segmental vitiligo mmp 9 tenascin surgical therapy in vitiligo nb-uvb |
| title | Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo |
| title_full | Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo |
| title_fullStr | Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo |
| title_full_unstemmed | Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo |
| title_short | Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo |
| title_sort | value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo |
| topic | non segmental vitiligo mmp 9 tenascin surgical therapy in vitiligo nb-uvb |
| url | http://dx.doi.org/10.1080/09546634.2020.1751038 |
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