Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets
The objective of this study is to evaluate the effects of organic acids on piglet growth performance and health status. A total of 360 weanling pigs (5.3 ± 0.6 kg) were randomly allotted to 3 treatment groups with 12 replicates of 10 pigs/pen. Piglets were fed the same basal diet and given either wa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/11/1665 |
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| author | Xin-Dong Xiang Zhang-Chao Deng You-Wei Wang Hua Sun Li Wang Yan-Ming Han Yuan-Yuan Wu Jian-Gao Liu Lv-Hui Sun |
| author_facet | Xin-Dong Xiang Zhang-Chao Deng You-Wei Wang Hua Sun Li Wang Yan-Ming Han Yuan-Yuan Wu Jian-Gao Liu Lv-Hui Sun |
| author_sort | Xin-Dong Xiang |
| collection | DOAJ |
| description | The objective of this study is to evaluate the effects of organic acids on piglet growth performance and health status. A total of 360 weanling pigs (5.3 ± 0.6 kg) were randomly allotted to 3 treatment groups with 12 replicates of 10 pigs/pen. Piglets were fed the same basal diet and given either water (control) or water plus 2.0 L/Ton organic acid (OA) blends, such as OA1 or OA2, respectively, for 7 weeks. Compared to the control, OA1 and OA2 improved growth performance and/or reduced the piglets’ diarrhea rate during the various periods and improved small intestinal morphology at days 14 and/or 49. OA1 and OA2 also increased serum CAT and SOD activities and/or T-AOC and, as expected, decreased MDA concentration. Moreover, at day 14 and/or day 49, OA1 and OA2 increased the jejunal mRNA levels of host defense peptides (<i>PBD1</i>, <i>PBD2</i>, <i>NPG1,</i> and <i>NPG3</i>) and tight junction genes (claudin-1) and decreased that of cytokines (<i>IL-1β</i> and <i>IL-2</i>). Additionally, the two acidifiers regulated the abundance of several cecum bacterial genera, including <i>Blautia</i>, <i>Bulleidia</i>, <i>Coprococcus</i>, <i>Dorea</i>, <i>Eubacterium</i>, <i>Subdoligranulum,</i> and <i>YRC2</i>. In conclusion, both of the organic acid blends improved piglet growth performance and health status, potentially by regulating intestinal redox homeostasis, immunity, and microflora. |
| first_indexed | 2024-03-10T05:44:51Z |
| format | Article |
| id | doaj.art-1def00f2188a49d1bc09237d632e68d4 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:44:51Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1def00f2188a49d1bc09237d632e68d42023-11-22T22:11:53ZengMDPI AGAntioxidants2076-39212021-10-011011166510.3390/antiox10111665Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned PigletsXin-Dong Xiang0Zhang-Chao Deng1You-Wei Wang2Hua Sun3Li Wang4Yan-Ming Han5Yuan-Yuan Wu6Jian-Gao Liu7Lv-Hui Sun8Hubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaHubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaHubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medicine Science, Hubei University of Medicine, Shiyan 442000, ChinaHubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, ChinaTrouw Nutrition, 773811 Amersfoort, The NetherlandsTrouw Nutrition, 773811 Amersfoort, The NetherlandsGuangzhou Liuhe Feed Company Limited, Guangzhou 511400, ChinaHubei Hongshan Laboratory, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaThe objective of this study is to evaluate the effects of organic acids on piglet growth performance and health status. A total of 360 weanling pigs (5.3 ± 0.6 kg) were randomly allotted to 3 treatment groups with 12 replicates of 10 pigs/pen. Piglets were fed the same basal diet and given either water (control) or water plus 2.0 L/Ton organic acid (OA) blends, such as OA1 or OA2, respectively, for 7 weeks. Compared to the control, OA1 and OA2 improved growth performance and/or reduced the piglets’ diarrhea rate during the various periods and improved small intestinal morphology at days 14 and/or 49. OA1 and OA2 also increased serum CAT and SOD activities and/or T-AOC and, as expected, decreased MDA concentration. Moreover, at day 14 and/or day 49, OA1 and OA2 increased the jejunal mRNA levels of host defense peptides (<i>PBD1</i>, <i>PBD2</i>, <i>NPG1,</i> and <i>NPG3</i>) and tight junction genes (claudin-1) and decreased that of cytokines (<i>IL-1β</i> and <i>IL-2</i>). Additionally, the two acidifiers regulated the abundance of several cecum bacterial genera, including <i>Blautia</i>, <i>Bulleidia</i>, <i>Coprococcus</i>, <i>Dorea</i>, <i>Eubacterium</i>, <i>Subdoligranulum,</i> and <i>YRC2</i>. In conclusion, both of the organic acid blends improved piglet growth performance and health status, potentially by regulating intestinal redox homeostasis, immunity, and microflora.https://www.mdpi.com/2076-3921/10/11/1665weanling pigsacidifiersperformanceredox statusimmunitygut microbiota |
| spellingShingle | Xin-Dong Xiang Zhang-Chao Deng You-Wei Wang Hua Sun Li Wang Yan-Ming Han Yuan-Yuan Wu Jian-Gao Liu Lv-Hui Sun Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets Antioxidants weanling pigs acidifiers performance redox status immunity gut microbiota |
| title | Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets |
| title_full | Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets |
| title_fullStr | Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets |
| title_full_unstemmed | Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets |
| title_short | Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets |
| title_sort | organic acids improve growth performance with potential regulation of redox homeostasis immunity and microflora in intestines of weaned piglets |
| topic | weanling pigs acidifiers performance redox status immunity gut microbiota |
| url | https://www.mdpi.com/2076-3921/10/11/1665 |
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