Radioactive iodine therapy: multiple faces of the same polyhedron
ABSTRACT The incidence of differentiated thyroid carcinoma (DTC) has increased in recent decades with early stage, low risk papillary thyroid cancer (PTC) being detected and diagnosed. As a result, the psychological, financial, and clinical ramifications of overdiagnosis and excessively aggressive t...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2022-05-01
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| Series: | Archives of Endocrinology and Metabolism |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000300393&tlng=en |
| _version_ | 1811215221724807168 |
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| author | Rosália do Prado Padovani Sumedha V. Chablani Robert Michael Tuttle |
| author_facet | Rosália do Prado Padovani Sumedha V. Chablani Robert Michael Tuttle |
| author_sort | Rosália do Prado Padovani |
| collection | DOAJ |
| description | ABSTRACT The incidence of differentiated thyroid carcinoma (DTC) has increased in recent decades with early stage, low risk papillary thyroid cancer (PTC) being detected and diagnosed. As a result, the psychological, financial, and clinical ramifications of overdiagnosis and excessively aggressive therapy are being increasingly recognized with many authorities calling for a re-evaluation of the traditional “one size fits all” management approaches. To address these critical issues, most thyroid cancer guidelines endorse a more risk adapted management strategy where the intensity of therapy and follow up is matched to the anticipated risk of recurrence and death from DTC for each patient. This “less is more” strategy provides for a minimalistic management approach for properly selected patients with low-risk DTC. This has re-kindled the long-standing debate regarding the routine use of radioactive iodine therapy (RIT) in DTC. Although recent guidelines have moved toward a more selective use of RIT, particular in patients with low-intermediate risk DTC, the proper selection of patients, the expected benefit, and the potential risks continue to be a source of ongoing controversy and debate. In this manuscript, we will review the wide range of clinical, imaging, medical team, and patient factors that must be considered when evaluating individual patients for RIT. Through a review of the current literature evaluating the potential benefits and risks of RIT, we will present a risk adapted approach to proper patient selection for RIT which emphasizes peri-operative risk stratification as the primary tool that clinicians should use to guide initial RIT management recommendations. |
| first_indexed | 2024-04-12T06:18:59Z |
| format | Article |
| id | doaj.art-1def05c159744ad481b76d6a627b2f03 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-12T06:18:59Z |
| publishDate | 2022-05-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-1def05c159744ad481b76d6a627b2f032022-12-22T03:44:22ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922022-05-0166339340610.20945/2359-3997000000461Radioactive iodine therapy: multiple faces of the same polyhedronRosália do Prado Padovanihttps://orcid.org/0000-0002-5497-6813Sumedha V. Chablanihttps://orcid.org/0000-0002-6695-9885Robert Michael Tuttlehttps://orcid.org/0000-0001-9899-9702ABSTRACT The incidence of differentiated thyroid carcinoma (DTC) has increased in recent decades with early stage, low risk papillary thyroid cancer (PTC) being detected and diagnosed. As a result, the psychological, financial, and clinical ramifications of overdiagnosis and excessively aggressive therapy are being increasingly recognized with many authorities calling for a re-evaluation of the traditional “one size fits all” management approaches. To address these critical issues, most thyroid cancer guidelines endorse a more risk adapted management strategy where the intensity of therapy and follow up is matched to the anticipated risk of recurrence and death from DTC for each patient. This “less is more” strategy provides for a minimalistic management approach for properly selected patients with low-risk DTC. This has re-kindled the long-standing debate regarding the routine use of radioactive iodine therapy (RIT) in DTC. Although recent guidelines have moved toward a more selective use of RIT, particular in patients with low-intermediate risk DTC, the proper selection of patients, the expected benefit, and the potential risks continue to be a source of ongoing controversy and debate. In this manuscript, we will review the wide range of clinical, imaging, medical team, and patient factors that must be considered when evaluating individual patients for RIT. Through a review of the current literature evaluating the potential benefits and risks of RIT, we will present a risk adapted approach to proper patient selection for RIT which emphasizes peri-operative risk stratification as the primary tool that clinicians should use to guide initial RIT management recommendations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000300393&tlng=en |
| spellingShingle | Rosália do Prado Padovani Sumedha V. Chablani Robert Michael Tuttle Radioactive iodine therapy: multiple faces of the same polyhedron Archives of Endocrinology and Metabolism |
| title | Radioactive iodine therapy: multiple faces of the same polyhedron |
| title_full | Radioactive iodine therapy: multiple faces of the same polyhedron |
| title_fullStr | Radioactive iodine therapy: multiple faces of the same polyhedron |
| title_full_unstemmed | Radioactive iodine therapy: multiple faces of the same polyhedron |
| title_short | Radioactive iodine therapy: multiple faces of the same polyhedron |
| title_sort | radioactive iodine therapy multiple faces of the same polyhedron |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022000300393&tlng=en |
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