Nasal polyps in patients with asthma: prevalence, impact, and management challenges
Cristobal Langdon,1,2 Joaquim Mullol1–3 1Rhinology Unit and Smell Clinic, Otorhinolaryngology Department, Hospital Clínic, 2Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 3Centre...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-03-01
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| Series: | Journal of Asthma and Allergy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/nasal-polyps-in-patients-with-asthma-prevalence-impact-and-management--peer-reviewed-article-JAA |
| _version_ | 1811265062449446912 |
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| author | Langdon C Mullol J |
| author_facet | Langdon C Mullol J |
| author_sort | Langdon C |
| collection | DOAJ |
| description | Cristobal Langdon,1,2 Joaquim Mullol1–3 1Rhinology Unit and Smell Clinic, Otorhinolaryngology Department, Hospital Clínic, 2Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 3Centre for Biomedical Research in Respiratory Diseases (CIBERES), Barcelona, Catalonia, SpainAbstract: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have coexisting asthma under the concept of “United Airway Disease”, being the combination of both diseases, which is one of the most challenging phenotypes to treat. Although clinicians have recognized this difficult-to-treat phenotype for many years, it remained poorly characterized. There is increasing epidemiological evidence linking chronic rhinosinusitis and asthma, but a good understanding of the pathophysiology and the combined management is still lacking. Bronchial asthma is more prevalent in patients who suffer chronic rhinosinusitis, while asthmatic patients have a greater prevalence of CRSwNP than patients without asthma. The effect of CRSwNP treatment, whether medical or surgical, in asthma is today less controversial after some studies have shown improvement of asthma after medical and/or surgical treatment of CRSwNP. However, direct comparisons between surgical and medical treatments are limited. Further randomized clinical trials are, however, still needed to better understand the management when both asthma and CRSwNP occur together. This review aims at summarizing the prevalence, impact, and management challenges regarding both asthma and CRSwNP. Keywords: chronic rhinosinusitis, asthma, united airways, rhinosinusitis, corticosteroids, sinus surgery |
| first_indexed | 2024-04-12T20:15:41Z |
| format | Article |
| id | doaj.art-1df07a7ec3374eb08db211d615333958 |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-04-12T20:15:41Z |
| publishDate | 2016-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-1df07a7ec3374eb08db211d6153339582022-12-22T03:18:08ZengDove Medical PressJournal of Asthma and Allergy1178-69652016-03-012016Issue 1455325975Nasal polyps in patients with asthma: prevalence, impact, and management challengesLangdon CMullol JCristobal Langdon,1,2 Joaquim Mullol1–3 1Rhinology Unit and Smell Clinic, Otorhinolaryngology Department, Hospital Clínic, 2Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 3Centre for Biomedical Research in Respiratory Diseases (CIBERES), Barcelona, Catalonia, SpainAbstract: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have coexisting asthma under the concept of “United Airway Disease”, being the combination of both diseases, which is one of the most challenging phenotypes to treat. Although clinicians have recognized this difficult-to-treat phenotype for many years, it remained poorly characterized. There is increasing epidemiological evidence linking chronic rhinosinusitis and asthma, but a good understanding of the pathophysiology and the combined management is still lacking. Bronchial asthma is more prevalent in patients who suffer chronic rhinosinusitis, while asthmatic patients have a greater prevalence of CRSwNP than patients without asthma. The effect of CRSwNP treatment, whether medical or surgical, in asthma is today less controversial after some studies have shown improvement of asthma after medical and/or surgical treatment of CRSwNP. However, direct comparisons between surgical and medical treatments are limited. Further randomized clinical trials are, however, still needed to better understand the management when both asthma and CRSwNP occur together. This review aims at summarizing the prevalence, impact, and management challenges regarding both asthma and CRSwNP. Keywords: chronic rhinosinusitis, asthma, united airways, rhinosinusitis, corticosteroids, sinus surgeryhttps://www.dovepress.com/nasal-polyps-in-patients-with-asthma-prevalence-impact-and-management--peer-reviewed-article-JAAChronic rhinosinusitisAsthmaUnited airwaysRhinosinusitisCorticosteroidsSinus surgery |
| spellingShingle | Langdon C Mullol J Nasal polyps in patients with asthma: prevalence, impact, and management challenges Journal of Asthma and Allergy Chronic rhinosinusitis Asthma United airways Rhinosinusitis Corticosteroids Sinus surgery |
| title | Nasal polyps in patients with asthma: prevalence, impact, and management challenges |
| title_full | Nasal polyps in patients with asthma: prevalence, impact, and management challenges |
| title_fullStr | Nasal polyps in patients with asthma: prevalence, impact, and management challenges |
| title_full_unstemmed | Nasal polyps in patients with asthma: prevalence, impact, and management challenges |
| title_short | Nasal polyps in patients with asthma: prevalence, impact, and management challenges |
| title_sort | nasal polyps in patients with asthma prevalence impact and management challenges |
| topic | Chronic rhinosinusitis Asthma United airways Rhinosinusitis Corticosteroids Sinus surgery |
| url | https://www.dovepress.com/nasal-polyps-in-patients-with-asthma-prevalence-impact-and-management--peer-reviewed-article-JAA |
| work_keys_str_mv | AT langdonc nasalpolypsinpatientswithasthmaprevalenceimpactandmanagementchallenges AT mullolj nasalpolypsinpatientswithasthmaprevalenceimpactandmanagementchallenges |