Recurrent network model for learning goal-directed sequences through reverse replay
Reverse replay of hippocampal place cells occurs frequently at rewarded locations, suggesting its contribution to goal-directed path learning. Symmetric spike-timing dependent plasticity (STDP) in CA3 likely potentiates recurrent synapses for both forward (start to goal) and reverse (goal to start)...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/34171 |
| _version_ | 1811235957763997696 |
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| author | Tatsuya Haga Tomoki Fukai |
| author_facet | Tatsuya Haga Tomoki Fukai |
| author_sort | Tatsuya Haga |
| collection | DOAJ |
| description | Reverse replay of hippocampal place cells occurs frequently at rewarded locations, suggesting its contribution to goal-directed path learning. Symmetric spike-timing dependent plasticity (STDP) in CA3 likely potentiates recurrent synapses for both forward (start to goal) and reverse (goal to start) replays during sequential activation of place cells. However, how reverse replay selectively strengthens forward synaptic pathway is unclear. Here, we show computationally that firing sequences bias synaptic transmissions to the opposite direction of propagation under symmetric STDP in the co-presence of short-term synaptic depression or afterdepolarization. We demonstrate that significant biases are created in biologically realistic simulation settings, and this bias enables reverse replay to enhance goal-directed spatial memory on a W-maze. Further, we show that essentially the same mechanism works in a two-dimensional open field. Our model for the first time provides the mechanistic account for the way reverse replay contributes to hippocampal sequence learning for reward-seeking spatial navigation. |
| first_indexed | 2024-04-12T12:01:00Z |
| format | Article |
| id | doaj.art-1df2b2200efb4c51840d691b7fc4f9a8 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:01:00Z |
| publishDate | 2018-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1df2b2200efb4c51840d691b7fc4f9a82022-12-22T03:33:51ZengeLife Sciences Publications LtdeLife2050-084X2018-07-01710.7554/eLife.34171Recurrent network model for learning goal-directed sequences through reverse replayTatsuya Haga0https://orcid.org/0000-0003-3145-709XTomoki Fukai1https://orcid.org/0000-0001-6977-5638RIKEN Center for Brain Science, Wako, JapanRIKEN Center for Brain Science, Wako, JapanReverse replay of hippocampal place cells occurs frequently at rewarded locations, suggesting its contribution to goal-directed path learning. Symmetric spike-timing dependent plasticity (STDP) in CA3 likely potentiates recurrent synapses for both forward (start to goal) and reverse (goal to start) replays during sequential activation of place cells. However, how reverse replay selectively strengthens forward synaptic pathway is unclear. Here, we show computationally that firing sequences bias synaptic transmissions to the opposite direction of propagation under symmetric STDP in the co-presence of short-term synaptic depression or afterdepolarization. We demonstrate that significant biases are created in biologically realistic simulation settings, and this bias enables reverse replay to enhance goal-directed spatial memory on a W-maze. Further, we show that essentially the same mechanism works in a two-dimensional open field. Our model for the first time provides the mechanistic account for the way reverse replay contributes to hippocampal sequence learning for reward-seeking spatial navigation.https://elifesciences.org/articles/34171hippocampusreverse replaysequence learningshort-term plasticityspike-timing-dependent plasticitygoal-directed learning |
| spellingShingle | Tatsuya Haga Tomoki Fukai Recurrent network model for learning goal-directed sequences through reverse replay eLife hippocampus reverse replay sequence learning short-term plasticity spike-timing-dependent plasticity goal-directed learning |
| title | Recurrent network model for learning goal-directed sequences through reverse replay |
| title_full | Recurrent network model for learning goal-directed sequences through reverse replay |
| title_fullStr | Recurrent network model for learning goal-directed sequences through reverse replay |
| title_full_unstemmed | Recurrent network model for learning goal-directed sequences through reverse replay |
| title_short | Recurrent network model for learning goal-directed sequences through reverse replay |
| title_sort | recurrent network model for learning goal directed sequences through reverse replay |
| topic | hippocampus reverse replay sequence learning short-term plasticity spike-timing-dependent plasticity goal-directed learning |
| url | https://elifesciences.org/articles/34171 |
| work_keys_str_mv | AT tatsuyahaga recurrentnetworkmodelforlearninggoaldirectedsequencesthroughreversereplay AT tomokifukai recurrentnetworkmodelforlearninggoaldirectedsequencesthroughreversereplay |