Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets.
Propranolol hydrochloride is a beta-blocker used for the management and treatment of hypertension, angina, coronary artery disease, heart failure, fibrillation, tremors, migraine etc. The objective of the present study was to design Propranolol Hydrochloride floating tablets by direct compression me...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0271442 |
| _version_ | 1811302543935930368 |
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| author | Salman Mehmood Syed Muhammad Farid Hasan Rabia Noor Muhammad Sikandar Syed Nadeem Ul Hasan Mohani Fauzia Israr Syed Imran Ali Majeed Ullah Fouzia Hassan |
| author_facet | Salman Mehmood Syed Muhammad Farid Hasan Rabia Noor Muhammad Sikandar Syed Nadeem Ul Hasan Mohani Fauzia Israr Syed Imran Ali Majeed Ullah Fouzia Hassan |
| author_sort | Salman Mehmood |
| collection | DOAJ |
| description | Propranolol hydrochloride is a beta-blocker used for the management and treatment of hypertension, angina, coronary artery disease, heart failure, fibrillation, tremors, migraine etc. The objective of the present study was to design Propranolol Hydrochloride floating tablets by direct compression method and to explore the role of a new gum as a matrix former. A 22 full factorial design was selected for the present study. Prunus domestica gum and HPMC (K4M) were used as independent variables, swelling index and drug dissolution at 12 hours as dependent variables. Formulations were subjected to pre- and post-compression tests that showed good micromeritics and buoyancy characteristics (Carr's index 11.76%-14.00%, Hausner's ratio 1.13°-1.16°, angle of repose 22.67°-25.21°, floating lag time 56-76 seconds, total floating time 18-25 hours and swelling index 59.87%-139.66%). The cumulative drug release in 0.1 N HCl at 12 hours was 72%-90% (p<0.05). Weibull model was found to be the best fit model (R2>0.99) among all other studied models. Multiple regression showed a significant effect of Prunus domestica gum and HPMC K4M on the swelling index and dissolution profiles of propranolol HCl (p<0.05). On the basis of better in-vitro performance and cost-effectiveness, formulation F4 was the best formulation. It is evident from the results that Prunus domestica gum possesses excellent drug release retardant potential for the floating drug delivery system and this new gum should be further explored alone or with other natural and synthetic polymers in future studies. |
| first_indexed | 2024-04-13T07:29:55Z |
| format | Article |
| id | doaj.art-1df2f727264345ea82934ce6d817e049 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T07:29:55Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1df2f727264345ea82934ce6d817e0492022-12-22T02:56:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178e027144210.1371/journal.pone.0271442Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets.Salman MehmoodSyed Muhammad Farid HasanRabia NoorMuhammad SikandarSyed Nadeem Ul Hasan MohaniFauzia IsrarSyed Imran AliMajeed UllahFouzia HassanPropranolol hydrochloride is a beta-blocker used for the management and treatment of hypertension, angina, coronary artery disease, heart failure, fibrillation, tremors, migraine etc. The objective of the present study was to design Propranolol Hydrochloride floating tablets by direct compression method and to explore the role of a new gum as a matrix former. A 22 full factorial design was selected for the present study. Prunus domestica gum and HPMC (K4M) were used as independent variables, swelling index and drug dissolution at 12 hours as dependent variables. Formulations were subjected to pre- and post-compression tests that showed good micromeritics and buoyancy characteristics (Carr's index 11.76%-14.00%, Hausner's ratio 1.13°-1.16°, angle of repose 22.67°-25.21°, floating lag time 56-76 seconds, total floating time 18-25 hours and swelling index 59.87%-139.66%). The cumulative drug release in 0.1 N HCl at 12 hours was 72%-90% (p<0.05). Weibull model was found to be the best fit model (R2>0.99) among all other studied models. Multiple regression showed a significant effect of Prunus domestica gum and HPMC K4M on the swelling index and dissolution profiles of propranolol HCl (p<0.05). On the basis of better in-vitro performance and cost-effectiveness, formulation F4 was the best formulation. It is evident from the results that Prunus domestica gum possesses excellent drug release retardant potential for the floating drug delivery system and this new gum should be further explored alone or with other natural and synthetic polymers in future studies.https://doi.org/10.1371/journal.pone.0271442 |
| spellingShingle | Salman Mehmood Syed Muhammad Farid Hasan Rabia Noor Muhammad Sikandar Syed Nadeem Ul Hasan Mohani Fauzia Israr Syed Imran Ali Majeed Ullah Fouzia Hassan Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets. PLoS ONE |
| title | Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets. |
| title_full | Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets. |
| title_fullStr | Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets. |
| title_full_unstemmed | Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets. |
| title_short | Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets. |
| title_sort | influence of prunus domestica gum on the release profiles of propranolol hcl floating tablets |
| url | https://doi.org/10.1371/journal.pone.0271442 |
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