Unraveling function and diversity of bacterial lectins in the human microbiome
Lectins are non-enzymatic carbohydrate binding proteins important to human cellular functions. Here, the authors characterize a lectin produced by a human associated bacterium, and show that interacts with myeloid cells in the blood and intestine, suggesting commensal microbiota lectins as a diverse...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29949-3 |
| _version_ | 1811258281241346048 |
|---|---|
| author | Louis J. Cohen Sun M. Han Pearson Lau Daniela Guisado Yupu Liang Toshiki G. Nakashige Thamina Ali David Chiang Adeeb Rahman Sean F. Brady |
| author_facet | Louis J. Cohen Sun M. Han Pearson Lau Daniela Guisado Yupu Liang Toshiki G. Nakashige Thamina Ali David Chiang Adeeb Rahman Sean F. Brady |
| author_sort | Louis J. Cohen |
| collection | DOAJ |
| description | Lectins are non-enzymatic carbohydrate binding proteins important to human cellular functions. Here, the authors characterize a lectin produced by a human associated bacterium, and show that interacts with myeloid cells in the blood and intestine, suggesting commensal microbiota lectins as a diverse and widespread mechanism to interact with host physiology. |
| first_indexed | 2024-04-12T18:10:49Z |
| format | Article |
| id | doaj.art-1df5145a09fe429d8021a79dc2379add |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T18:10:49Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1df5145a09fe429d8021a79dc2379add2022-12-22T03:21:50ZengNature PortfolioNature Communications2041-17232022-06-0113111210.1038/s41467-022-29949-3Unraveling function and diversity of bacterial lectins in the human microbiomeLouis J. Cohen0Sun M. Han1Pearson Lau2Daniela Guisado3Yupu Liang4Toshiki G. Nakashige5Thamina Ali6David Chiang7Adeeb Rahman8Sean F. Brady9Department of Medicine, Icahn Genomics Institute, Icahn School of Medicine at Mount SinaiDepartment of Medicine, Icahn Genomics Institute, Icahn School of Medicine at Mount SinaiDepartment of Medicine, Icahn Genomics Institute, Icahn School of Medicine at Mount SinaiDepartment of Medicine, Icahn Genomics Institute, Icahn School of Medicine at Mount SinaiRockefeller UniversityLaboratory of Genetically Encoded Small Molecules, Rockefeller UniversityLaboratory of Genetically Encoded Small Molecules, Rockefeller UniversityDivision of Internal Medicine-Pediatrics, University of Massachusetts Medical SchoolHuman Immune Monitoring Core, Icahn School of Medicine at Mount SinaiLaboratory of Genetically Encoded Small Molecules, Rockefeller UniversityLectins are non-enzymatic carbohydrate binding proteins important to human cellular functions. Here, the authors characterize a lectin produced by a human associated bacterium, and show that interacts with myeloid cells in the blood and intestine, suggesting commensal microbiota lectins as a diverse and widespread mechanism to interact with host physiology.https://doi.org/10.1038/s41467-022-29949-3 |
| spellingShingle | Louis J. Cohen Sun M. Han Pearson Lau Daniela Guisado Yupu Liang Toshiki G. Nakashige Thamina Ali David Chiang Adeeb Rahman Sean F. Brady Unraveling function and diversity of bacterial lectins in the human microbiome Nature Communications |
| title | Unraveling function and diversity of bacterial lectins in the human microbiome |
| title_full | Unraveling function and diversity of bacterial lectins in the human microbiome |
| title_fullStr | Unraveling function and diversity of bacterial lectins in the human microbiome |
| title_full_unstemmed | Unraveling function and diversity of bacterial lectins in the human microbiome |
| title_short | Unraveling function and diversity of bacterial lectins in the human microbiome |
| title_sort | unraveling function and diversity of bacterial lectins in the human microbiome |
| url | https://doi.org/10.1038/s41467-022-29949-3 |
| work_keys_str_mv | AT louisjcohen unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT sunmhan unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT pearsonlau unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT danielaguisado unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT yupuliang unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT toshikignakashige unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT thaminaali unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT davidchiang unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT adeebrahman unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome AT seanfbrady unravelingfunctionanddiversityofbacteriallectinsinthehumanmicrobiome |