Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men
Abstract Background Metabolic profiling may provide insights into the pathogenesis and identification of sarcopenia; however, data on the metabolic basis of sarcopenia and muscle-related parameters among older adults remain incompletely understood. This study aimed to identify the associations of me...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-02953-4 |
| _version_ | 1819177027945627648 |
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| author | Li Meng Ruiyue Yang Daguang Wang Wenbin Wu Jing Shi Ji Shen Yamin Dang Guoqing Fan Hong Shi Jun Dong Huan Xi Pulin Yu |
| author_facet | Li Meng Ruiyue Yang Daguang Wang Wenbin Wu Jing Shi Ji Shen Yamin Dang Guoqing Fan Hong Shi Jun Dong Huan Xi Pulin Yu |
| author_sort | Li Meng |
| collection | DOAJ |
| description | Abstract Background Metabolic profiling may provide insights into the pathogenesis and identification of sarcopenia; however, data on the metabolic basis of sarcopenia and muscle-related parameters among older adults remain incompletely understood. This study aimed to identify the associations of metabolites with sarcopenia and its components, and to explore metabolic perturbations in older men, who have a higher prevalence of sarcopenia than women. Methods We simultaneously measured the concentrations of amino acids, carnitine, acylcarnitines, and lysophosphatidylcholines (LPCs) in serum samples from a cross-sectional study of 246 Chinese older men, using targeted metabolomics. Sarcopenia and its components, including skeletal muscle index (SMI), 6-m gait speed, and handgrip strength were assessed according to the algorithm of the Asian Working Group for Sarcopenia criteria. Associations were determined by univariate and multivariate analyses. Results Sixty-five (26.4%) older men with sarcopenia and 181 (73.6%) without sarcopenia were included in the study. The level of isovalerylcarnitine (C5) was associated with the presence of sarcopenia and SMI. Regarding the overlapped metabolites for muscle parameters, among ten metabolites associated with muscle mass, six metabolites including leucine, octanoyl-L-carnitine (C8), decanoyl-L-carnitine (C10), dodecanoyl-L-carnitine (C12) and tetradecanoyl-L-carnitine (C14), and LPC18:2 were associated with handgrip strength, and three of which (C12, C14, and LPC18:2) were also associated with gait speed. Specifically, tryptophan was positively associated and glycine was negatively associated with handgrip strength, while glutamate was positively correlated with gait speed. Isoleucine, branched chain amino acids, and LPC16:0 were positively associated with SMI. Moreover, the levels of LPC 16:0,18:2 and 18:0 contributed significantly to the model discriminating between older men with and without sarcopenia, whereas there were no significant associations for other amino acids, acylcarnitines, and LPC lipids. Conclusions These results showed that specific and overlapped metabolites are associated with sarcopenic parameters in older men. This study highlights the potential roles of acylcarnitines and LPCs in sarcopenia and its components, which may provide valuable information regarding the pathogenesis and management of sarcopenia. |
| first_indexed | 2024-12-22T21:20:08Z |
| format | Article |
| id | doaj.art-1df5626d0b88495db5664ddcc94e3f78 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-22T21:20:08Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-1df5626d0b88495db5664ddcc94e3f782022-12-21T18:12:13ZengBMCBMC Geriatrics1471-23182022-03-0122111310.1186/s12877-022-02953-4Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older menLi Meng0Ruiyue Yang1Daguang Wang2Wenbin Wu3Jing Shi4Ji Shen5Yamin Dang6Guoqing Fan7Hong Shi8Jun Dong9Huan Xi10Pulin Yu11Department of Geriatrics, National Clinical Research Center for Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health CommissionDepartment of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesDepartment of Geriatrics, National Clinical Research Center for Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health CommissionDepartment of Geriatrics, National Clinical Research Center for Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health CommissionThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health CommissionDepartment of Geriatrics, National Clinical Research Center for Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health CommissionDepartment of Geriatrics, National Clinical Research Center for Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical SciencesThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health CommissionAbstract Background Metabolic profiling may provide insights into the pathogenesis and identification of sarcopenia; however, data on the metabolic basis of sarcopenia and muscle-related parameters among older adults remain incompletely understood. This study aimed to identify the associations of metabolites with sarcopenia and its components, and to explore metabolic perturbations in older men, who have a higher prevalence of sarcopenia than women. Methods We simultaneously measured the concentrations of amino acids, carnitine, acylcarnitines, and lysophosphatidylcholines (LPCs) in serum samples from a cross-sectional study of 246 Chinese older men, using targeted metabolomics. Sarcopenia and its components, including skeletal muscle index (SMI), 6-m gait speed, and handgrip strength were assessed according to the algorithm of the Asian Working Group for Sarcopenia criteria. Associations were determined by univariate and multivariate analyses. Results Sixty-five (26.4%) older men with sarcopenia and 181 (73.6%) without sarcopenia were included in the study. The level of isovalerylcarnitine (C5) was associated with the presence of sarcopenia and SMI. Regarding the overlapped metabolites for muscle parameters, among ten metabolites associated with muscle mass, six metabolites including leucine, octanoyl-L-carnitine (C8), decanoyl-L-carnitine (C10), dodecanoyl-L-carnitine (C12) and tetradecanoyl-L-carnitine (C14), and LPC18:2 were associated with handgrip strength, and three of which (C12, C14, and LPC18:2) were also associated with gait speed. Specifically, tryptophan was positively associated and glycine was negatively associated with handgrip strength, while glutamate was positively correlated with gait speed. Isoleucine, branched chain amino acids, and LPC16:0 were positively associated with SMI. Moreover, the levels of LPC 16:0,18:2 and 18:0 contributed significantly to the model discriminating between older men with and without sarcopenia, whereas there were no significant associations for other amino acids, acylcarnitines, and LPC lipids. Conclusions These results showed that specific and overlapped metabolites are associated with sarcopenic parameters in older men. This study highlights the potential roles of acylcarnitines and LPCs in sarcopenia and its components, which may provide valuable information regarding the pathogenesis and management of sarcopenia.https://doi.org/10.1186/s12877-022-02953-4SarcopeniaMuscleMetabolomicsBiomarkersMultivariate analysesOlder men |
| spellingShingle | Li Meng Ruiyue Yang Daguang Wang Wenbin Wu Jing Shi Ji Shen Yamin Dang Guoqing Fan Hong Shi Jun Dong Huan Xi Pulin Yu Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men BMC Geriatrics Sarcopenia Muscle Metabolomics Biomarkers Multivariate analyses Older men |
| title | Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men |
| title_full | Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men |
| title_fullStr | Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men |
| title_full_unstemmed | Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men |
| title_short | Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men |
| title_sort | specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men |
| topic | Sarcopenia Muscle Metabolomics Biomarkers Multivariate analyses Older men |
| url | https://doi.org/10.1186/s12877-022-02953-4 |
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