Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine
The bioactive alkaloids (e.g. vincristine, hydroxycamptothecin, ligustrazine, and so on) from traditional Chinese medicine (TCM) have exerted potent efficacies (e.g. anti-tumor, anti-inflammation, immunosuppression, etc.). However, a series of undesirable physicochemical properties (like low solubil...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
|
| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2018.1431980 |
| _version_ | 1819023248579362816 |
|---|---|
| author | Xiao Zheng Fei Wu Xiao Lin Lan Shen Yi Feng |
| author_facet | Xiao Zheng Fei Wu Xiao Lin Lan Shen Yi Feng |
| author_sort | Xiao Zheng |
| collection | DOAJ |
| description | The bioactive alkaloids (e.g. vincristine, hydroxycamptothecin, ligustrazine, and so on) from traditional Chinese medicine (TCM) have exerted potent efficacies (e.g. anti-tumor, anti-inflammation, immunosuppression, etc.). However, a series of undesirable physicochemical properties (like low solubility and weak stability) and baneful pharmacokinetic (PK) profiles (e.g. low bioavailability, short half time, rapid clearance, etc.) have severely restricted their applications in clinic. In addition, some side effects (like cumulative toxicities caused by high-frequency administration and their own toxicities) have recently been reported and also confined their clinical uses. Therefore, developments in drug delivery of such alkaloids are of significance in improving their drug-like properties and, thus, treatment efficiencies in clinic. Strategies, including (i) specific delivery via liposomes; (ii) sustained delivery via nanoparticles, gels, and emulsions; and (iii) transdermal delivery via ethosomes, solid lipid nanoparticles, and penetrating enhancers, have been reported to improve the pharmacokinetic and physicochemical characters of problematic TCM alkaloids, decline their adverse effects, and thus, boost their curative efficacies. In this review, the recent reports in this field were comprehensively summarized with the aim of providing an informative reference for relevant readers. |
| first_indexed | 2024-12-21T04:35:53Z |
| format | Article |
| id | doaj.art-1df864172dff45219228306b33201579 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-21T04:35:53Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-1df864172dff45219228306b332015792022-12-21T19:15:51ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642018-01-0125139841610.1080/10717544.2018.14319801431980Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicineXiao Zheng0Fei Wu1Xiao Lin2Lan Shen3Yi Feng4Shanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineThe bioactive alkaloids (e.g. vincristine, hydroxycamptothecin, ligustrazine, and so on) from traditional Chinese medicine (TCM) have exerted potent efficacies (e.g. anti-tumor, anti-inflammation, immunosuppression, etc.). However, a series of undesirable physicochemical properties (like low solubility and weak stability) and baneful pharmacokinetic (PK) profiles (e.g. low bioavailability, short half time, rapid clearance, etc.) have severely restricted their applications in clinic. In addition, some side effects (like cumulative toxicities caused by high-frequency administration and their own toxicities) have recently been reported and also confined their clinical uses. Therefore, developments in drug delivery of such alkaloids are of significance in improving their drug-like properties and, thus, treatment efficiencies in clinic. Strategies, including (i) specific delivery via liposomes; (ii) sustained delivery via nanoparticles, gels, and emulsions; and (iii) transdermal delivery via ethosomes, solid lipid nanoparticles, and penetrating enhancers, have been reported to improve the pharmacokinetic and physicochemical characters of problematic TCM alkaloids, decline their adverse effects, and thus, boost their curative efficacies. In this review, the recent reports in this field were comprehensively summarized with the aim of providing an informative reference for relevant readers.http://dx.doi.org/10.1080/10717544.2018.1431980bioactive alkaloidstraditional chinese medicinepharmacokineticstoxicitydrug delivery |
| spellingShingle | Xiao Zheng Fei Wu Xiao Lin Lan Shen Yi Feng Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine Drug Delivery bioactive alkaloids traditional chinese medicine pharmacokinetics toxicity drug delivery |
| title | Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine |
| title_full | Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine |
| title_fullStr | Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine |
| title_full_unstemmed | Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine |
| title_short | Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine |
| title_sort | developments in drug delivery of bioactive alkaloids derived from traditional chinese medicine |
| topic | bioactive alkaloids traditional chinese medicine pharmacokinetics toxicity drug delivery |
| url | http://dx.doi.org/10.1080/10717544.2018.1431980 |
| work_keys_str_mv | AT xiaozheng developmentsindrugdeliveryofbioactivealkaloidsderivedfromtraditionalchinesemedicine AT feiwu developmentsindrugdeliveryofbioactivealkaloidsderivedfromtraditionalchinesemedicine AT xiaolin developmentsindrugdeliveryofbioactivealkaloidsderivedfromtraditionalchinesemedicine AT lanshen developmentsindrugdeliveryofbioactivealkaloidsderivedfromtraditionalchinesemedicine AT yifeng developmentsindrugdeliveryofbioactivealkaloidsderivedfromtraditionalchinesemedicine |