SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
Interleukin-17 (IL-17)-secreting CD4 T cells (Th17) are induced by the master transcription factor RORγt, and are important for anti-fungal immunity and inflammatory responses. Here the authors show that Ubc9-mediated SUMOylation of RORγt induces HDAC2 binding to IL-17 promoter for suppressing IL-17...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06924-5 |
| _version_ | 1818716823478075392 |
|---|---|
| author | Amir Kumar Singh Prashant Khare Abeer Obaid Kevin P. Conlon Venkatesha Basrur Ronald A. DePinho K. Venuprasad |
| author_facet | Amir Kumar Singh Prashant Khare Abeer Obaid Kevin P. Conlon Venkatesha Basrur Ronald A. DePinho K. Venuprasad |
| author_sort | Amir Kumar Singh |
| collection | DOAJ |
| description | Interleukin-17 (IL-17)-secreting CD4 T cells (Th17) are induced by the master transcription factor RORγt, and are important for anti-fungal immunity and inflammatory responses. Here the authors show that Ubc9-mediated SUMOylation of RORγt induces HDAC2 binding to IL-17 promoter for suppressing IL-17 production in Th17 cells. |
| first_indexed | 2024-12-17T19:25:23Z |
| format | Article |
| id | doaj.art-1df8e582f787431da6877b852dc40340 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T19:25:23Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1df8e582f787431da6877b852dc403402022-12-21T21:35:24ZengNature PortfolioNature Communications2041-17232018-10-019111110.1038/s41467-018-06924-5SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2Amir Kumar Singh0Prashant Khare1Abeer Obaid2Kevin P. Conlon3Venkatesha Basrur4Ronald A. DePinho5K. Venuprasad6Baylor Institute for Immunology Research, Baylor Scott & White Research InstituteBaylor Institute for Immunology Research, Baylor Scott & White Research InstituteBaylor Institute for Immunology Research, Baylor Scott & White Research InstituteDepartment of Pathology, University of MichiganDepartment of Pathology, University of MichiganDepartment of Cancer Biology, The University of Texas MD Anderson Cancer CenterBaylor Institute for Immunology Research, Baylor Scott & White Research InstituteInterleukin-17 (IL-17)-secreting CD4 T cells (Th17) are induced by the master transcription factor RORγt, and are important for anti-fungal immunity and inflammatory responses. Here the authors show that Ubc9-mediated SUMOylation of RORγt induces HDAC2 binding to IL-17 promoter for suppressing IL-17 production in Th17 cells.https://doi.org/10.1038/s41467-018-06924-5 |
| spellingShingle | Amir Kumar Singh Prashant Khare Abeer Obaid Kevin P. Conlon Venkatesha Basrur Ronald A. DePinho K. Venuprasad SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 Nature Communications |
| title | SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 |
| title_full | SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 |
| title_fullStr | SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 |
| title_full_unstemmed | SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 |
| title_short | SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 |
| title_sort | sumoylation of ror γt inhibits il 17 expression and inflammation via hdac2 |
| url | https://doi.org/10.1038/s41467-018-06924-5 |
| work_keys_str_mv | AT amirkumarsingh sumoylationofrorgtinhibitsil17expressionandinflammationviahdac2 AT prashantkhare sumoylationofrorgtinhibitsil17expressionandinflammationviahdac2 AT abeerobaid sumoylationofrorgtinhibitsil17expressionandinflammationviahdac2 AT kevinpconlon sumoylationofrorgtinhibitsil17expressionandinflammationviahdac2 AT venkateshabasrur sumoylationofrorgtinhibitsil17expressionandinflammationviahdac2 AT ronaldadepinho sumoylationofrorgtinhibitsil17expressionandinflammationviahdac2 AT kvenuprasad sumoylationofrorgtinhibitsil17expressionandinflammationviahdac2 |