Twentyfourhour oesophageal pH studies in rural Eastern Cape Province South Africa
Background. Recent studies in rural Eastern Cape Province, South Africa, have shown an increased number of non-acid gastro-oesophageal reflux events, an increase in baseline gastric pH compared with other published series, and evidence suggestive of duodenogastric reflux. There are no published data...
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| Format: | Article |
| Language: | English |
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South African Medical Association
2018-10-01
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| Series: | South African Medical Journal |
| Online Access: | http://www.samj.org.za/index.php/samj/article/download/12461/8667 |
| _version_ | 1797331600589979648 |
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| author | E Ndebia A Sammon |
| author_facet | E Ndebia A Sammon |
| author_sort | E Ndebia |
| collection | DOAJ |
| description | Background. Recent studies in rural Eastern Cape Province, South Africa, have shown an increased number of non-acid gastro-oesophageal reflux events, an increase in baseline gastric pH compared with other published series, and evidence suggestive of duodenogastric reflux. There are no published data on oesophageal pH in this community or in Africa.Objectives. To ascertain whether oesophageal pH in this rural community is within normal limits.Methods. We carried out 24-hour oesophageal pH/impedance studies on 91 participants. Analysis was carried out using computer software to determine 24-hour percentage times of oesophageal pH above 4, 5, 6, 7 and 8. Oesophageal pH during each episode of non-acid reflux was also recorded.Results. Participants were from Canzibe in rural Eastern Cape. Of the studies, 72 were satisfactory and showed 24-hour percentage times with an oesophageal pH >6 of 69.3/35.12/51.16 (upright/supine/total); percentage times with a pH >7 were 12.66/3.44/8.86 and those with a pH >8 were 0.48/0.21/0.37. These results are within the range of other published series. Of episodes of non-acid reflux, 90.2% were associated with an oesophageal pH of 4 - 7.Conclusions. Baseline oesophageal pH is not significantly affected by the increased numbers of non-acid gastro-oesophageal reflux events reported in this community. If there is a pathogenic effect of non-acid reflux in the Eastern Cape, it does not appear to be mediated through raised oesophageal pH. |
| first_indexed | 2024-03-08T07:37:50Z |
| format | Article |
| id | doaj.art-1df99e2a19eb4d02bb525d4ba6edbeef |
| institution | Directory Open Access Journal |
| issn | 0256-9574 2078-5135 |
| language | English |
| last_indexed | 2024-03-08T07:37:50Z |
| publishDate | 2018-10-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Medical Journal |
| spelling | doaj.art-1df99e2a19eb4d02bb525d4ba6edbeef2024-02-02T18:14:04ZengSouth African Medical AssociationSouth African Medical Journal0256-95742078-51352018-10-011081195795910.7196/SAMJ.2018.v108i11.13227Twentyfourhour oesophageal pH studies in rural Eastern Cape Province South AfricaE NdebiaA SammonBackground. Recent studies in rural Eastern Cape Province, South Africa, have shown an increased number of non-acid gastro-oesophageal reflux events, an increase in baseline gastric pH compared with other published series, and evidence suggestive of duodenogastric reflux. There are no published data on oesophageal pH in this community or in Africa.Objectives. To ascertain whether oesophageal pH in this rural community is within normal limits.Methods. We carried out 24-hour oesophageal pH/impedance studies on 91 participants. Analysis was carried out using computer software to determine 24-hour percentage times of oesophageal pH above 4, 5, 6, 7 and 8. Oesophageal pH during each episode of non-acid reflux was also recorded.Results. Participants were from Canzibe in rural Eastern Cape. Of the studies, 72 were satisfactory and showed 24-hour percentage times with an oesophageal pH >6 of 69.3/35.12/51.16 (upright/supine/total); percentage times with a pH >7 were 12.66/3.44/8.86 and those with a pH >8 were 0.48/0.21/0.37. These results are within the range of other published series. Of episodes of non-acid reflux, 90.2% were associated with an oesophageal pH of 4 - 7.Conclusions. Baseline oesophageal pH is not significantly affected by the increased numbers of non-acid gastro-oesophageal reflux events reported in this community. If there is a pathogenic effect of non-acid reflux in the Eastern Cape, it does not appear to be mediated through raised oesophageal pH.Âhttp://www.samj.org.za/index.php/samj/article/download/12461/8667 |
| spellingShingle | E Ndebia A Sammon Twentyfourhour oesophageal pH studies in rural Eastern Cape Province South Africa South African Medical Journal |
| title | Twentyfourhour oesophageal pH studies in rural Eastern Cape Province South Africa |
| title_full | Twentyfourhour oesophageal pH studies in rural Eastern Cape Province South Africa |
| title_fullStr | Twentyfourhour oesophageal pH studies in rural Eastern Cape Province South Africa |
| title_full_unstemmed | Twentyfourhour oesophageal pH studies in rural Eastern Cape Province South Africa |
| title_short | Twentyfourhour oesophageal pH studies in rural Eastern Cape Province South Africa |
| title_sort | twentyfourhour oesophageal ph studies in rural eastern cape province south africa |
| url | http://www.samj.org.za/index.php/samj/article/download/12461/8667 |
| work_keys_str_mv | AT endebia twentyfourhouroesophagealphstudiesinruraleasterncapeprovincesouthafrica AT asammon twentyfourhouroesophagealphstudiesinruraleasterncapeprovincesouthafrica |