O emprego de lipases como agentes de resolução cinética de enantiômeros em síntese orgânica: aspectos gerais sobre a influência do solvente
In organic synthesis, lipases are the most frequently used biocatalysts. They are efficient stereoselective catalysts in the kinetic resolution of a wide variety of chiral compounds. The discovery that enzymes possess catalytic activity in organic solvents has made it possible to address the questio...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
1999-01-01
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| Series: | Química Nova |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000600014 |
| _version_ | 1819298192748969984 |
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| author | Costa Valentim Emilio Uberti Amorim Hermes Luís Neubauer de |
| author_facet | Costa Valentim Emilio Uberti Amorim Hermes Luís Neubauer de |
| author_sort | Costa Valentim Emilio Uberti |
| collection | DOAJ |
| description | In organic synthesis, lipases are the most frequently used biocatalysts. They are efficient stereoselective catalysts in the kinetic resolution of a wide variety of chiral compounds. The discovery that enzymes possess catalytic activity in organic solvents has made it possible to address the question of reaction medium influence on enzymatic specificity. Perhaps the most exciting and significant development in this emerging area is the discovery that enzyme specificity, in particular enantioselectivity, can be affected by changing from one organic solvent to another. This article discusses the scope and possible mechanistic models of this phenomenon in hydrolases, specially lipases, as well as directions of future research in the area. |
| first_indexed | 2024-12-24T05:26:00Z |
| format | Article |
| id | doaj.art-1dfa39d2dc684516b7a644e93fa28d87 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-24T05:26:00Z |
| publishDate | 1999-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-1dfa39d2dc684516b7a644e93fa28d872022-12-21T17:13:19ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70641999-01-01226863873O emprego de lipases como agentes de resolução cinética de enantiômeros em síntese orgânica: aspectos gerais sobre a influência do solventeCosta Valentim Emilio UbertiAmorim Hermes Luís Neubauer deIn organic synthesis, lipases are the most frequently used biocatalysts. They are efficient stereoselective catalysts in the kinetic resolution of a wide variety of chiral compounds. The discovery that enzymes possess catalytic activity in organic solvents has made it possible to address the question of reaction medium influence on enzymatic specificity. Perhaps the most exciting and significant development in this emerging area is the discovery that enzyme specificity, in particular enantioselectivity, can be affected by changing from one organic solvent to another. This article discusses the scope and possible mechanistic models of this phenomenon in hydrolases, specially lipases, as well as directions of future research in the area.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000600014lipase enantioselectivitysolventmechanistic models |
| spellingShingle | Costa Valentim Emilio Uberti Amorim Hermes Luís Neubauer de O emprego de lipases como agentes de resolução cinética de enantiômeros em síntese orgânica: aspectos gerais sobre a influência do solvente Química Nova lipase enantioselectivity solvent mechanistic models |
| title | O emprego de lipases como agentes de resolução cinética de enantiômeros em síntese orgânica: aspectos gerais sobre a influência do solvente |
| title_full | O emprego de lipases como agentes de resolução cinética de enantiômeros em síntese orgânica: aspectos gerais sobre a influência do solvente |
| title_fullStr | O emprego de lipases como agentes de resolução cinética de enantiômeros em síntese orgânica: aspectos gerais sobre a influência do solvente |
| title_full_unstemmed | O emprego de lipases como agentes de resolução cinética de enantiômeros em síntese orgânica: aspectos gerais sobre a influência do solvente |
| title_short | O emprego de lipases como agentes de resolução cinética de enantiômeros em síntese orgânica: aspectos gerais sobre a influência do solvente |
| title_sort | o emprego de lipases como agentes de resolucao cinetica de enantiomeros em sintese organica aspectos gerais sobre a influencia do solvente |
| topic | lipase enantioselectivity solvent mechanistic models |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000600014 |
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