Development and clinical evaluation of a CRISPR/Cas13a-based diagnostic test to detect Mycobacterium tuberculosis in clinical specimens

Development and clinical evaluation of a CRISPR/Cas13a-based diagnostic test to detect Mycobacterium tuberculosis in clinical specimens

ObjectiveTuberculosis diagnosis requires rapid, simple and highly sensitive methods. Clustered regularly interspaced short palindromic repeats (CRISPRs) and associated protein (Cas) systems are increasingly being used for clinical diagnostic applications, due to their high flexibility, sensitivity a...

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Bibliographic Details
Main Authors: Weicong Ren, You Zhou, Haoran Li, Yuanyuan Shang, Xuxia Zhang, Jinfeng Yuan, Shanshan Li, Chuanyou Li, Yu Pang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Microbiology
Subjects:
tuberculosis
Mycobacterium tuberculosis complex (MTB)
GeneXpert MTB/RIF
CRISPR
PCR
diagnosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1117085/full

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