Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures
<i>Purpose</i>: Seizures related to tumor growth are common in glioma patients, especially in low-grade glioma patients this is often the first tumor manifestation. We hypothesize that there are associations between preoperative seizures and morphologic features (e.g., tumor size, locati...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/4/994 |
| _version_ | 1797570296467685376 |
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| author | Stefanie Bette Melanie Barz Huong Ly Nham Thomas Huber Maria Berndt Arthur Sales Friederike Schmidt-Graf Hanno S. Meyer Yu-Mi Ryang Bernhard Meyer Claus Zimmer Jan S. Kirschke Benedikt Wiestler Jens Gempt |
| author_facet | Stefanie Bette Melanie Barz Huong Ly Nham Thomas Huber Maria Berndt Arthur Sales Friederike Schmidt-Graf Hanno S. Meyer Yu-Mi Ryang Bernhard Meyer Claus Zimmer Jan S. Kirschke Benedikt Wiestler Jens Gempt |
| author_sort | Stefanie Bette |
| collection | DOAJ |
| description | <i>Purpose</i>: Seizures related to tumor growth are common in glioma patients, especially in low-grade glioma patients this is often the first tumor manifestation. We hypothesize that there are associations between preoperative seizures and morphologic features (e.g., tumor size, location) and histogram features in patients with glioblastoma (GB). <i>Methods</i>: Retrospectively, 160 consecutive patients with initial diagnosis and surgery of GB (WHO IV) and preoperative MRI were analyzed. Preoperative MRI sequences were co-registered (T2-FLAIR, T1-contrast, DTI) and tumors were segmented by a neuroradiologist using the software ITK-snap blinded to the clinical data. Tumor volume (FLAIR, T1-contrast) and histogram analyses of ADC- and FA-maps were recorded in the contrast enhancing tumor part (CET) and the non-enhancing peritumoral edema (FLAIR). Location was determined after co-registration of the data with an atlas. Permutation-based multiple-testing adjusted t statistics were calculated to compare imaging variables between patients with and without seizures. <i>Results</i>: Patients with seizures showed significantly smaller tumors (CET, adj. <i>p</i> = 0.029) than patients without preoperative seizures. Less seizures were observed in patients with tumor location in the right cingulate gyrus (adj. <i>p</i> = 0.048) and in the right caudate nucleus (adj. <i>p</i> = 0.009). Significant differences of histogram analyses of FA in the contrast enhancing tumor part were observed between patients with and without seizures considering also tumor location and size. <i>Conclusion</i>: Preoperative seizures in GB patients are associated with lower preoperative tumor volume. The different histogram analyses suggest that there might be microstructural differences in the contrast enhancing tumor part of patients with seizures measured by fractional anisotropy. Higher variance of GB presenting without seizures might indicate a more aggressive growth of these tumors. |
| first_indexed | 2024-03-10T20:23:55Z |
| format | Article |
| id | doaj.art-1dfc43643c4545c9b2592f4fa62330ba |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T20:23:55Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1dfc43643c4545c9b2592f4fa62330ba2023-11-19T21:56:56ZengMDPI AGCancers2072-66942020-04-0112499410.3390/cancers12040994Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative SeizuresStefanie Bette0Melanie Barz1Huong Ly Nham2Thomas Huber3Maria Berndt4Arthur Sales5Friederike Schmidt-Graf6Hanno S. Meyer7Yu-Mi Ryang8Bernhard Meyer9Claus Zimmer10Jan S. Kirschke11Benedikt Wiestler12Jens Gempt13Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1–3, 68167 Mannheim, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neurology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany<i>Purpose</i>: Seizures related to tumor growth are common in glioma patients, especially in low-grade glioma patients this is often the first tumor manifestation. We hypothesize that there are associations between preoperative seizures and morphologic features (e.g., tumor size, location) and histogram features in patients with glioblastoma (GB). <i>Methods</i>: Retrospectively, 160 consecutive patients with initial diagnosis and surgery of GB (WHO IV) and preoperative MRI were analyzed. Preoperative MRI sequences were co-registered (T2-FLAIR, T1-contrast, DTI) and tumors were segmented by a neuroradiologist using the software ITK-snap blinded to the clinical data. Tumor volume (FLAIR, T1-contrast) and histogram analyses of ADC- and FA-maps were recorded in the contrast enhancing tumor part (CET) and the non-enhancing peritumoral edema (FLAIR). Location was determined after co-registration of the data with an atlas. Permutation-based multiple-testing adjusted t statistics were calculated to compare imaging variables between patients with and without seizures. <i>Results</i>: Patients with seizures showed significantly smaller tumors (CET, adj. <i>p</i> = 0.029) than patients without preoperative seizures. Less seizures were observed in patients with tumor location in the right cingulate gyrus (adj. <i>p</i> = 0.048) and in the right caudate nucleus (adj. <i>p</i> = 0.009). Significant differences of histogram analyses of FA in the contrast enhancing tumor part were observed between patients with and without seizures considering also tumor location and size. <i>Conclusion</i>: Preoperative seizures in GB patients are associated with lower preoperative tumor volume. The different histogram analyses suggest that there might be microstructural differences in the contrast enhancing tumor part of patients with seizures measured by fractional anisotropy. Higher variance of GB presenting without seizures might indicate a more aggressive growth of these tumors.https://www.mdpi.com/2072-6694/12/4/994seizuresglioblastomadiffusion-tensor-imaging |
| spellingShingle | Stefanie Bette Melanie Barz Huong Ly Nham Thomas Huber Maria Berndt Arthur Sales Friederike Schmidt-Graf Hanno S. Meyer Yu-Mi Ryang Bernhard Meyer Claus Zimmer Jan S. Kirschke Benedikt Wiestler Jens Gempt Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures Cancers seizures glioblastoma diffusion-tensor-imaging |
| title | Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures |
| title_full | Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures |
| title_fullStr | Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures |
| title_full_unstemmed | Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures |
| title_short | Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures |
| title_sort | image analysis reveals microstructural and volumetric differences in glioblastoma patients with and without preoperative seizures |
| topic | seizures glioblastoma diffusion-tensor-imaging |
| url | https://www.mdpi.com/2072-6694/12/4/994 |
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