Metamorphopsia associated with central retinal vein occlusion.
This prospective study aimed to investigate metamorphopsia in eyes with central retinal vein occlusion (CRVO) and included 28 eyes (28 patients) with unilateral CRVO that had macular edema (ME) in the acute phase. The ME was treated with anti-vascular endothelial growth factor agents. At baseline an...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5648234?pdf=render |
| _version_ | 1819176834676293632 |
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| author | Koichiro Manabe Rie Osaka Yuki Nakano Yukari Takasago Tomoyoshi Fujita Chieko Shiragami Kazuyuki Hirooka Yuki Muraoka Akitaka Tsujikawa |
| author_facet | Koichiro Manabe Rie Osaka Yuki Nakano Yukari Takasago Tomoyoshi Fujita Chieko Shiragami Kazuyuki Hirooka Yuki Muraoka Akitaka Tsujikawa |
| author_sort | Koichiro Manabe |
| collection | DOAJ |
| description | This prospective study aimed to investigate metamorphopsia in eyes with central retinal vein occlusion (CRVO) and included 28 eyes (28 patients) with unilateral CRVO that had macular edema (ME) in the acute phase. The ME was treated with anti-vascular endothelial growth factor agents. At baseline and at 1 and 6 months after initiation of treatment, quantitative measurements of metamorphopsia were performed using M-CHARTS and the retinal morphologic changes were examined by optical coherence tomography. At baseline, metamorphopsia was detected on M-CHARTS in 14 (50.0%) eyes. The mean M-CHARTS score was 0.37 ± 0.53. At 1 month and 6 months after initiation of treatment, there was substantial resolution of ME and significant recovery of visual acuity. In contrast, metamorphopsia was still detected in 16 eyes at 6 months; the mean M-CHARTS scores were 0.29 ± 0.37 at 1 month and 0.32 ± 0.38 at 6 months, and had not significantly improved from baseline (p = 0.580, and p = 0.604, respectively). Although the M-CHARTS score at 6 months was associated with the baseline M-CHARTS score (p = 0.004), it did not have any associations with morphologic parameters at baseline. However, the M-CHARTS score at 6 months was significantly associated with foveal photoreceptor status, height of serous detachment, and parafoveal thickening at 1 month. Metamorphopsia associated with CRVO could be quantified using M-CHARTS, and often persisted in contrast with the recovery of visual acuity and resolution of ME after treatment with anti-vascular endothelial growth factor agents. |
| first_indexed | 2024-12-22T21:17:04Z |
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| id | doaj.art-1dfc689a7b6c42cf8a2d8e57ff212f9f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T21:17:04Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-1dfc689a7b6c42cf8a2d8e57ff212f9f2022-12-21T18:12:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011210e018673710.1371/journal.pone.0186737Metamorphopsia associated with central retinal vein occlusion.Koichiro ManabeRie OsakaYuki NakanoYukari TakasagoTomoyoshi FujitaChieko ShiragamiKazuyuki HirookaYuki MuraokaAkitaka TsujikawaThis prospective study aimed to investigate metamorphopsia in eyes with central retinal vein occlusion (CRVO) and included 28 eyes (28 patients) with unilateral CRVO that had macular edema (ME) in the acute phase. The ME was treated with anti-vascular endothelial growth factor agents. At baseline and at 1 and 6 months after initiation of treatment, quantitative measurements of metamorphopsia were performed using M-CHARTS and the retinal morphologic changes were examined by optical coherence tomography. At baseline, metamorphopsia was detected on M-CHARTS in 14 (50.0%) eyes. The mean M-CHARTS score was 0.37 ± 0.53. At 1 month and 6 months after initiation of treatment, there was substantial resolution of ME and significant recovery of visual acuity. In contrast, metamorphopsia was still detected in 16 eyes at 6 months; the mean M-CHARTS scores were 0.29 ± 0.37 at 1 month and 0.32 ± 0.38 at 6 months, and had not significantly improved from baseline (p = 0.580, and p = 0.604, respectively). Although the M-CHARTS score at 6 months was associated with the baseline M-CHARTS score (p = 0.004), it did not have any associations with morphologic parameters at baseline. However, the M-CHARTS score at 6 months was significantly associated with foveal photoreceptor status, height of serous detachment, and parafoveal thickening at 1 month. Metamorphopsia associated with CRVO could be quantified using M-CHARTS, and often persisted in contrast with the recovery of visual acuity and resolution of ME after treatment with anti-vascular endothelial growth factor agents.http://europepmc.org/articles/PMC5648234?pdf=render |
| spellingShingle | Koichiro Manabe Rie Osaka Yuki Nakano Yukari Takasago Tomoyoshi Fujita Chieko Shiragami Kazuyuki Hirooka Yuki Muraoka Akitaka Tsujikawa Metamorphopsia associated with central retinal vein occlusion. PLoS ONE |
| title | Metamorphopsia associated with central retinal vein occlusion. |
| title_full | Metamorphopsia associated with central retinal vein occlusion. |
| title_fullStr | Metamorphopsia associated with central retinal vein occlusion. |
| title_full_unstemmed | Metamorphopsia associated with central retinal vein occlusion. |
| title_short | Metamorphopsia associated with central retinal vein occlusion. |
| title_sort | metamorphopsia associated with central retinal vein occlusion |
| url | http://europepmc.org/articles/PMC5648234?pdf=render |
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