Epidemiology and Survival of Patients With Optic Pathway Gliomas: A Population-Based Analysis
BackgroundWe aimed to analyze the epidemiology and outcomes of pediatric patients and adult patients with optic pathway gliomas in the United States using a population-based method.MethodsData for patients with optic pathway gliomas diagnosed between 2000 and 2018 were extracted from the SEER databa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.789856/full |
| _version_ | 1818331459231940608 |
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| author | Huanbing Liu Yong Chen Xiaowei Qin Zheng Jin Yining Jiang Yubo Wang |
| author_facet | Huanbing Liu Yong Chen Xiaowei Qin Zheng Jin Yining Jiang Yubo Wang |
| author_sort | Huanbing Liu |
| collection | DOAJ |
| description | BackgroundWe aimed to analyze the epidemiology and outcomes of pediatric patients and adult patients with optic pathway gliomas in the United States using a population-based method.MethodsData for patients with optic pathway gliomas diagnosed between 2000 and 2018 were extracted from the SEER database. We divided the patients into a pediatric group and an adult group. Descriptive analyses were conducted to analyze demographic and clinical characteristics and treatment. We used the chi-square test to evaluate differences between pediatric and adult patients with optic pathway gliomas. The possible prognostic indicators were analyzed by Kaplan–Meier curves and Cox proportional hazards models.ResultsOptic pathway gliomas represented 86.6% of all lesions originating from the optic pathway. In total, 1257 cases of optic pathway gliomas were included in our study. Pediatric patients accounted for 83.7% in this cohort, and most of the patients were diagnosed at 1-4 years old. Chemotherapy was chosen most often for pediatric patients, but radiation therapy was chosen most often for adult patients. Pilocytic astrocytoma accounted for 59.1% of pediatric patients and 37.5% of adult patients. The overall survival (OS) rates were 94.8% 5 years after diagnosis and 93.0% 10 years after diagnosis. Survival analysis showed that surgery, radiation and chemotherapy did not help patients obtain a better prognosis. Overall, pediatric patients had a better prognosis.ConclusionOptic pathway gliomas are relatively rare lesions with good prognosis. They mostly affect children, and pilocytic astrocytoma is the most common histological diagnosis. Highly individualized treatment is essential for such patients. |
| first_indexed | 2024-12-13T13:20:11Z |
| format | Article |
| id | doaj.art-1dfd4925df9545849322012d27a7b9b9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T13:20:11Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1dfd4925df9545849322012d27a7b9b92022-12-21T23:44:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-02-011210.3389/fonc.2022.789856789856Epidemiology and Survival of Patients With Optic Pathway Gliomas: A Population-Based AnalysisHuanbing LiuYong ChenXiaowei QinZheng JinYining JiangYubo WangBackgroundWe aimed to analyze the epidemiology and outcomes of pediatric patients and adult patients with optic pathway gliomas in the United States using a population-based method.MethodsData for patients with optic pathway gliomas diagnosed between 2000 and 2018 were extracted from the SEER database. We divided the patients into a pediatric group and an adult group. Descriptive analyses were conducted to analyze demographic and clinical characteristics and treatment. We used the chi-square test to evaluate differences between pediatric and adult patients with optic pathway gliomas. The possible prognostic indicators were analyzed by Kaplan–Meier curves and Cox proportional hazards models.ResultsOptic pathway gliomas represented 86.6% of all lesions originating from the optic pathway. In total, 1257 cases of optic pathway gliomas were included in our study. Pediatric patients accounted for 83.7% in this cohort, and most of the patients were diagnosed at 1-4 years old. Chemotherapy was chosen most often for pediatric patients, but radiation therapy was chosen most often for adult patients. Pilocytic astrocytoma accounted for 59.1% of pediatric patients and 37.5% of adult patients. The overall survival (OS) rates were 94.8% 5 years after diagnosis and 93.0% 10 years after diagnosis. Survival analysis showed that surgery, radiation and chemotherapy did not help patients obtain a better prognosis. Overall, pediatric patients had a better prognosis.ConclusionOptic pathway gliomas are relatively rare lesions with good prognosis. They mostly affect children, and pilocytic astrocytoma is the most common histological diagnosis. Highly individualized treatment is essential for such patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.789856/fullepidemiologysurvivalSEER programCNS diseaseoptic pathway glioma |
| spellingShingle | Huanbing Liu Yong Chen Xiaowei Qin Zheng Jin Yining Jiang Yubo Wang Epidemiology and Survival of Patients With Optic Pathway Gliomas: A Population-Based Analysis Frontiers in Oncology epidemiology survival SEER program CNS disease optic pathway glioma |
| title | Epidemiology and Survival of Patients With Optic Pathway Gliomas: A Population-Based Analysis |
| title_full | Epidemiology and Survival of Patients With Optic Pathway Gliomas: A Population-Based Analysis |
| title_fullStr | Epidemiology and Survival of Patients With Optic Pathway Gliomas: A Population-Based Analysis |
| title_full_unstemmed | Epidemiology and Survival of Patients With Optic Pathway Gliomas: A Population-Based Analysis |
| title_short | Epidemiology and Survival of Patients With Optic Pathway Gliomas: A Population-Based Analysis |
| title_sort | epidemiology and survival of patients with optic pathway gliomas a population based analysis |
| topic | epidemiology survival SEER program CNS disease optic pathway glioma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.789856/full |
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