Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials
An advancement in preventing secondary caries has been the incorporation of quaternary ammonium containing (QAC) compounds into a composite resin mixture. The permanent positive charge on the monomers allows for electrostatic-based killing of bacteria. Spontaneous adsorption of salivary proteins ont...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/11/3/54 |
| _version_ | 1797560590425653248 |
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| author | Leopoldo Torres Jr Diane R. Bienek |
| author_facet | Leopoldo Torres Jr Diane R. Bienek |
| author_sort | Leopoldo Torres Jr |
| collection | DOAJ |
| description | An advancement in preventing secondary caries has been the incorporation of quaternary ammonium containing (QAC) compounds into a composite resin mixture. The permanent positive charge on the monomers allows for electrostatic-based killing of bacteria. Spontaneous adsorption of salivary proteins onto restorations dampens the antimicrobial capabilities of QAC compounds. Protein-repellent monomers can work with QAC restorations to achieve the technology’s full potential. We discuss the theory behind macromolecular adsorption, direct and indirect characterization methods, and advances of protein repellent dental materials. The translation of protein adsorption to microbial colonization is covered, and the concerns and fallbacks of the state-of-the-art protein-resistant monomers are addressed. Last, we present new and exciting avenues for protein repellent monomer design that have yet to be explored in dental materials. |
| first_indexed | 2024-03-10T18:01:51Z |
| format | Article |
| id | doaj.art-1dfd78ff6005444b9bb7cc077fa10baa |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-10T18:01:51Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-1dfd78ff6005444b9bb7cc077fa10baa2023-11-20T08:45:00ZengMDPI AGJournal of Functional Biomaterials2079-49832020-08-011135410.3390/jfb11030054Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental MaterialsLeopoldo Torres Jr0Diane R. Bienek1ADA Science & Research Institute, LLC, Innovative & Technology Research, Frederick, MD 21704, USAADA Science & Research Institute, LLC, Innovative & Technology Research, Frederick, MD 21704, USAAn advancement in preventing secondary caries has been the incorporation of quaternary ammonium containing (QAC) compounds into a composite resin mixture. The permanent positive charge on the monomers allows for electrostatic-based killing of bacteria. Spontaneous adsorption of salivary proteins onto restorations dampens the antimicrobial capabilities of QAC compounds. Protein-repellent monomers can work with QAC restorations to achieve the technology’s full potential. We discuss the theory behind macromolecular adsorption, direct and indirect characterization methods, and advances of protein repellent dental materials. The translation of protein adsorption to microbial colonization is covered, and the concerns and fallbacks of the state-of-the-art protein-resistant monomers are addressed. Last, we present new and exciting avenues for protein repellent monomer design that have yet to be explored in dental materials.https://www.mdpi.com/2079-4983/11/3/54protein repellentrestorationszwitterionic polymersdental materialsantimicrobialantifouling |
| spellingShingle | Leopoldo Torres Jr Diane R. Bienek Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials Journal of Functional Biomaterials protein repellent restorations zwitterionic polymers dental materials antimicrobial antifouling |
| title | Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials |
| title_full | Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials |
| title_fullStr | Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials |
| title_full_unstemmed | Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials |
| title_short | Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials |
| title_sort | use of protein repellents to enhance the antimicrobial functionality of quaternary ammonium containing dental materials |
| topic | protein repellent restorations zwitterionic polymers dental materials antimicrobial antifouling |
| url | https://www.mdpi.com/2079-4983/11/3/54 |
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