Elevated neuronal excitability due to modulation of the voltage-gated sodium channel Nav1.6 by Aβ1-42

Elevated neuronal excitability due to modulation of the voltage-gated sodium channel Nav1.6 by Aβ1-42

Aberrant increases in neuronal network excitability may contribute to the cognitive deficits in Alzheimer’s disease (AD). However, the mechanisms underlying hyperexcitability are not fully understood. Such overexcitation of neuronal networks has been detected in the brains of APP/PS1 mice. In the pr...

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Bibliographic Details
Main Authors: Xi eWang, Xiao Gang eZhang, Zhou eTingting, Li eNa, Jiang eChunyan, Xiao eZhicheng, Ma eQuanhong, Shao eLi
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Neuroscience
Subjects:
neurodegeneration
Alzheimer's disease;
beta-amyloid peptide;
excitability;
voltage-gated sodium channel;
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00094/full

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