Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and autoimmunity has not been well defined. In this stu...

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Bibliographic Details
Main Authors: Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4031148?pdf=render

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