Molecular insights into the origin of the Hox-TALE patterning system
Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior–posterior axis. Hox proteins exert their function...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2014-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/01939 |
| _version_ | 1828375385562152960 |
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| author | Bruno Hudry Morgane Thomas-Chollier Yael Volovik Marilyne Duffraisse Amélie Dard Dale Frank Ulrich Technau Samir Merabet |
| author_facet | Bruno Hudry Morgane Thomas-Chollier Yael Volovik Marilyne Duffraisse Amélie Dard Dale Frank Ulrich Technau Samir Merabet |
| author_sort | Bruno Hudry |
| collection | DOAJ |
| description | Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior–posterior axis. Hox proteins exert their function by interaction with TALE transcription factors. Hox and TALE members are also present in some but not all non-bilaterian phyla, raising the question of how Hox–TALE interactions evolved to provide positional information. By using proteins from unicellular and multicellular lineages, we showed that these networks emerged from an ancestral generic motif present in Hox and other related protein families. Interestingly, Hox-TALE networks experienced additional and extensive molecular innovations that were likely crucial for differentiating Hox functions along body plans. Together our results highlight how homeobox gene families evolved during eukaryote evolution to eventually constitute a major patterning system in Eumetazoans. |
| first_indexed | 2024-04-14T07:46:49Z |
| format | Article |
| id | doaj.art-1e02995c6eee45dea1cd3479b5e5f3ea |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:46:49Z |
| publishDate | 2014-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1e02995c6eee45dea1cd3479b5e5f3ea2022-12-22T02:05:19ZengeLife Sciences Publications LtdeLife2050-084X2014-03-01310.7554/eLife.01939Molecular insights into the origin of the Hox-TALE patterning systemBruno Hudry0Morgane Thomas-Chollier1Yael Volovik2Marilyne Duffraisse3Amélie Dard4Dale Frank5Ulrich Technau6Samir Merabet7MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United KingdomUnité Mixte de Recherche (UMR) 8197, INSERM U1024, Institut de Biologie de l’ENS (IBENS), Ecole Normale Supérieure (ENS), Centre National de Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Scientifique (INSERM), Paris, FranceDepartment of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, IsraelUnité Mixte de Recherche (UMR) 5242, Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure (ENS) de Lyon, Centre National de Recherche Scientifique (CNRS), Lyon, FranceUnité Mixte de Recherche (UMR) 5242, Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure (ENS) de Lyon, Centre National de Recherche Scientifique (CNRS), Lyon, FranceDepartment of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, IsraelDepartment für Molekulare Evolution und Entwicklung, University of Vienna, Vienna, AustriaUnité Mixte de Recherche (UMR) 5242, Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure (ENS) de Lyon, Centre National de Recherche Scientifique (CNRS), Lyon, FranceDespite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior–posterior axis. Hox proteins exert their function by interaction with TALE transcription factors. Hox and TALE members are also present in some but not all non-bilaterian phyla, raising the question of how Hox–TALE interactions evolved to provide positional information. By using proteins from unicellular and multicellular lineages, we showed that these networks emerged from an ancestral generic motif present in Hox and other related protein families. Interestingly, Hox-TALE networks experienced additional and extensive molecular innovations that were likely crucial for differentiating Hox functions along body plans. Together our results highlight how homeobox gene families evolved during eukaryote evolution to eventually constitute a major patterning system in Eumetazoans.https://elifesciences.org/articles/01939HoxTALEevolutionnetworktranscription factorNematostella vectensis |
| spellingShingle | Bruno Hudry Morgane Thomas-Chollier Yael Volovik Marilyne Duffraisse Amélie Dard Dale Frank Ulrich Technau Samir Merabet Molecular insights into the origin of the Hox-TALE patterning system eLife Hox TALE evolution network transcription factor Nematostella vectensis |
| title | Molecular insights into the origin of the Hox-TALE patterning system |
| title_full | Molecular insights into the origin of the Hox-TALE patterning system |
| title_fullStr | Molecular insights into the origin of the Hox-TALE patterning system |
| title_full_unstemmed | Molecular insights into the origin of the Hox-TALE patterning system |
| title_short | Molecular insights into the origin of the Hox-TALE patterning system |
| title_sort | molecular insights into the origin of the hox tale patterning system |
| topic | Hox TALE evolution network transcription factor Nematostella vectensis |
| url | https://elifesciences.org/articles/01939 |
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