Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications
Abstract The most common cancer diagnosis in female population is breast cancer, which affects every year about 2.0 million women worldwide. In recent years, significant progress has been made in oncological therapy, in systemic treatment, and in radiotherapy of breast cancer. Unfortunately, the imp...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13365 |
| _version_ | 1818358934322282496 |
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| author | Agata Bikiewicz Maciej Banach Stephan vonHaehling Marek Maciejewski Agata Bielecka‐Dabrowa |
| author_facet | Agata Bikiewicz Maciej Banach Stephan vonHaehling Marek Maciejewski Agata Bielecka‐Dabrowa |
| author_sort | Agata Bikiewicz |
| collection | DOAJ |
| description | Abstract The most common cancer diagnosis in female population is breast cancer, which affects every year about 2.0 million women worldwide. In recent years, significant progress has been made in oncological therapy, in systemic treatment, and in radiotherapy of breast cancer. Unfortunately, the improvement in the effectiveness of oncological treatment and prolonging patients' life span is associated with more frequent occurrence of organ complications, which are side effects of this treatment. Current recommendations suggest a periodic monitoring of the cardiovascular system in course of oncological treatment. The monitoring includes the assessment of occurrence of risk factors for cardiovascular diseases in combination with the evaluation of the left ventricular systolic function using echocardiography and electrocardiography as well as with the analysis of the concentration of cardiac biomarkers. The aim of this review was critical assessment of the breast cancer therapy cardiotoxicity and the analysis of methods its detections. The new cardio‐specific biomarkers in serum, the development of modern imaging techniques (Global Longitudinal Strain and Three‐Dimensional Left Ventricular Ejection Fraction) and genotyping, and especially their combined use, may become a useful tool for identifying patients at risk of developing cardiotoxicity, who require further cardiovascular monitoring or cardioprotective therapy. |
| first_indexed | 2024-12-13T20:36:53Z |
| format | Article |
| id | doaj.art-1e031665993b40d98c042eeb704e0514 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-13T20:36:53Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-1e031665993b40d98c042eeb704e05142022-12-21T23:32:16ZengWileyESC Heart Failure2055-58222021-08-01842397241810.1002/ehf2.13365Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complicationsAgata Bikiewicz0Maciej Banach1Stephan vonHaehling2Marek Maciejewski3Agata Bielecka‐Dabrowa4Heart Failure Unit, Department of Cardiology and Congenital Diseases of Adults Polish Mother's Memorial Hospital Research Institute (PMMHRI) Rzgowska 281/289 Lodz 93‐338 PolandHeart Failure Unit, Department of Cardiology and Congenital Diseases of Adults Polish Mother's Memorial Hospital Research Institute (PMMHRI) Rzgowska 281/289 Lodz 93‐338 PolandDepartment of Cardiology and Pneumology and German Center for Cardiovascular Research (DZHK), partner site Göttingen University Medical Center Göttingen (UMG) Göttingen GermanyDepartment of Cardiology and Congenital Diseases of Adults Polish Mother's Memorial Hospital Research Institute (PMMHRI) Lodz PolandHeart Failure Unit, Department of Cardiology and Congenital Diseases of Adults Polish Mother's Memorial Hospital Research Institute (PMMHRI) Rzgowska 281/289 Lodz 93‐338 PolandAbstract The most common cancer diagnosis in female population is breast cancer, which affects every year about 2.0 million women worldwide. In recent years, significant progress has been made in oncological therapy, in systemic treatment, and in radiotherapy of breast cancer. Unfortunately, the improvement in the effectiveness of oncological treatment and prolonging patients' life span is associated with more frequent occurrence of organ complications, which are side effects of this treatment. Current recommendations suggest a periodic monitoring of the cardiovascular system in course of oncological treatment. The monitoring includes the assessment of occurrence of risk factors for cardiovascular diseases in combination with the evaluation of the left ventricular systolic function using echocardiography and electrocardiography as well as with the analysis of the concentration of cardiac biomarkers. The aim of this review was critical assessment of the breast cancer therapy cardiotoxicity and the analysis of methods its detections. The new cardio‐specific biomarkers in serum, the development of modern imaging techniques (Global Longitudinal Strain and Three‐Dimensional Left Ventricular Ejection Fraction) and genotyping, and especially their combined use, may become a useful tool for identifying patients at risk of developing cardiotoxicity, who require further cardiovascular monitoring or cardioprotective therapy.https://doi.org/10.1002/ehf2.13365CardiotoxicityHeart failureBreast cancerBiomarkersOncological treatment |
| spellingShingle | Agata Bikiewicz Maciej Banach Stephan vonHaehling Marek Maciejewski Agata Bielecka‐Dabrowa Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications ESC Heart Failure Cardiotoxicity Heart failure Breast cancer Biomarkers Oncological treatment |
| title | Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications |
| title_full | Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications |
| title_fullStr | Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications |
| title_full_unstemmed | Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications |
| title_short | Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications |
| title_sort | adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications |
| topic | Cardiotoxicity Heart failure Breast cancer Biomarkers Oncological treatment |
| url | https://doi.org/10.1002/ehf2.13365 |
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