Organoids: a systematic review of ethical issues
Abstract Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, ti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-02950-9 |
| _version_ | 1818192943566028800 |
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| author | Dide de Jongh Emma K. Massey the VANGUARD consortium Eline M. Bunnik |
| author_facet | Dide de Jongh Emma K. Massey the VANGUARD consortium Eline M. Bunnik |
| author_sort | Dide de Jongh |
| collection | DOAJ |
| description | Abstract Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue donors may perceive enduring personal connections with their organoids, setting higher bars for informed consent and patient participation. Also, several organoid sub-types, e.g., brain organoids and human–animal chimeric organoids, have raised controversy. This systematic review provides an overview of ethical discussions as conducted in the scientific literature on organoids. The review covers both research and clinical applications of organoid technology and discusses the topics informed consent, commercialization, personalized medicine, transplantation, brain organoids, chimeras, and gastruloids. It shows that further ethical research is needed especially on organoid transplantation, to help ensure the responsible development and clinical implementation of this technology in this field. |
| first_indexed | 2024-12-12T00:38:32Z |
| format | Article |
| id | doaj.art-1e044cc25189407796c86a74f2075501 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-12T00:38:32Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-1e044cc25189407796c86a74f20755012022-12-22T00:44:18ZengBMCStem Cell Research & Therapy1757-65122022-07-0113112110.1186/s13287-022-02950-9Organoids: a systematic review of ethical issuesDide de Jongh0Emma K. Massey1the VANGUARD consortiumEline M. Bunnik2Department of Nephrology and Transplantation, Erasmus MC, University Medical Centre RotterdamDepartment of Nephrology and Transplantation, Erasmus MC, University Medical Centre RotterdamDepartment of Medical Ethics, Philosophy and History of Medicine, Erasmus MC, University Medical Centre RotterdamAbstract Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue donors may perceive enduring personal connections with their organoids, setting higher bars for informed consent and patient participation. Also, several organoid sub-types, e.g., brain organoids and human–animal chimeric organoids, have raised controversy. This systematic review provides an overview of ethical discussions as conducted in the scientific literature on organoids. The review covers both research and clinical applications of organoid technology and discusses the topics informed consent, commercialization, personalized medicine, transplantation, brain organoids, chimeras, and gastruloids. It shows that further ethical research is needed especially on organoid transplantation, to help ensure the responsible development and clinical implementation of this technology in this field.https://doi.org/10.1186/s13287-022-02950-9OrganoidsEthicsResearch oversightInformed consentPersonalized medicineTransplantation |
| spellingShingle | Dide de Jongh Emma K. Massey the VANGUARD consortium Eline M. Bunnik Organoids: a systematic review of ethical issues Stem Cell Research & Therapy Organoids Ethics Research oversight Informed consent Personalized medicine Transplantation |
| title | Organoids: a systematic review of ethical issues |
| title_full | Organoids: a systematic review of ethical issues |
| title_fullStr | Organoids: a systematic review of ethical issues |
| title_full_unstemmed | Organoids: a systematic review of ethical issues |
| title_short | Organoids: a systematic review of ethical issues |
| title_sort | organoids a systematic review of ethical issues |
| topic | Organoids Ethics Research oversight Informed consent Personalized medicine Transplantation |
| url | https://doi.org/10.1186/s13287-022-02950-9 |
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