Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial
BackgroundLate-life depression (LLD) affects up to 18% of older adults and has been linked to elevated dementia risk. Mindfulness-based cognitive therapy (MBCT) holds promise for treating symptoms of depression and ameliorating cognitive deficits in older adults. While preliminary findings are promi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.976636/full |
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| author | Magnus Bein Myriam Lesage Elena Dikaios Mallar Chakravarty Zindel Segal Isabelle Royal Mark Speechley Alessandra Schiavetto Daniel Blumberger Matthew D. Sacchet Joseph Therriault Johanna Gruber Valerie Tourjman Stephane Richard-Devantoy Vasavan Nair Marie-Andrée Bruneau Soham Rej Soham Rej Michael Lifshitz Michael Lifshitz Harmehr Sekhon Harmehr Sekhon |
| author_facet | Magnus Bein Myriam Lesage Elena Dikaios Mallar Chakravarty Zindel Segal Isabelle Royal Mark Speechley Alessandra Schiavetto Daniel Blumberger Matthew D. Sacchet Joseph Therriault Johanna Gruber Valerie Tourjman Stephane Richard-Devantoy Vasavan Nair Marie-Andrée Bruneau Soham Rej Soham Rej Michael Lifshitz Michael Lifshitz Harmehr Sekhon Harmehr Sekhon |
| author_sort | Magnus Bein |
| collection | DOAJ |
| description | BackgroundLate-life depression (LLD) affects up to 18% of older adults and has been linked to elevated dementia risk. Mindfulness-based cognitive therapy (MBCT) holds promise for treating symptoms of depression and ameliorating cognitive deficits in older adults. While preliminary findings are promising, a definitive RCT investigating its effects on late life depression and cognition have not yet been conducted. We present a protocol describing a multi-site blinded randomized controlled trial, comparing the effects of MBCT and of an active control, a Health Enhancement Program (HEP), on depressive symptoms, executive functioning, and brain biomarkers of LLD, among several other exploratory outcomes.MethodsTwo-hundred and thirteen (n = 213) patients with LLD will be recruited at various centers in Montreal, QC, Canada. Participants will undergo stratified randomization to either MBCT or HEP intervention groups. We will assess changes in (1) depression severity using the Hamilton Depression Rating Scale (HAM-D17), (2) processing speed and executive functioning, (3) brain biomarkers of LLD (hippocampal volume, default network resting-state functional connectivity and executive network resting-state functional connectivity), and (4) other exploratory physiological and mood-based measures, at baseline (0 weeks), post intervention (8 weeks), and 26 weeks after baseline.DiscussionThe proposed study will assess the clinical potential of MBCT to improve symptoms of depression, as well as examine its impact on cognitive impairments and neurobiological markers, and thus inform its use as a promising adjunct in the treatment of LLD.Clinical trial registrationwww.ClinicalTrials.gov, identifier: NCT05366088. |
| first_indexed | 2024-04-11T11:19:03Z |
| format | Article |
| id | doaj.art-1e0541bb589e4a68863478d12e915ee7 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T11:19:03Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-1e0541bb589e4a68863478d12e915ee72022-12-22T04:27:08ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-09-011410.3389/fnagi.2022.976636976636Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trialMagnus Bein0Myriam Lesage1Elena Dikaios2Mallar Chakravarty3Zindel Segal4Isabelle Royal5Mark Speechley6Alessandra Schiavetto7Daniel Blumberger8Matthew D. Sacchet9Joseph Therriault10Johanna Gruber11Valerie Tourjman12Stephane Richard-Devantoy13Vasavan Nair14Marie-Andrée Bruneau15Soham Rej16Soham Rej17Michael Lifshitz18Michael Lifshitz19Harmehr Sekhon20Harmehr Sekhon21Department of Psychiatry, GeriPARTy Research Group, Jewish General Hospital, Montréal, QC, CanadaDepartment of Psychiatry, GeriPARTy Research Group, Jewish General Hospital, Montréal, QC, CanadaDepartment of Psychiatry, GeriPARTy Research Group, Jewish General Hospital, Montréal, QC, CanadaDepartments of Biological and Biomedical Engineering and Psychiatry, Centre d'imagerie cérébrale, Douglas Mental Health Institute, Verdun, QC, CanadaUniversity of Toronto–Scarborough, Toronto, ON, CanadaNeuropsychology Service, Department of Psychiatry, Jewish General Hospital, Montréal, QC, CanadaDepartment of Epidemiology and Biostatistics, University of Western Ontario, London, ON, CanadaDepartment of Psychiatry, Jewish General Hospital, McGill University, Montréal, QC, CanadaDepartment of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, CanadaMeditation Research Program, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology and Neurosurgery, Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Douglas Mental Health Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest de l'Île de Montréal, Montréal, QC, CanadaDepartment of Psychiatry, GeriPARTy Research Group, Jewish General Hospital, Montréal, QC, Canada0Department of Psychiatry, Institut Universitaire en Santé Mentale de Montréal, Montréal, QC, Canada1Department of Psychiatry, Douglas Mental Health Institute, Verdun, QC, Canada1Department of Psychiatry, Douglas Mental Health Institute, Verdun, QC, Canada2Département de psychiatrie et d'addictologie, Research Centre, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, CanadaDepartment of Psychiatry, GeriPARTy Research Group, Jewish General Hospital, Montréal, QC, CanadaDepartment of Psychiatry, Jewish General Hospital, McGill University, Montréal, QC, CanadaDepartment of Psychiatry, Jewish General Hospital, McGill University, Montréal, QC, Canada3Division of Social and Transcultural Psychiatry, Department of Psychiatry, McGill University, Montréal, QC, CanadaDepartment of Psychiatry, GeriPARTy Research Group, Jewish General Hospital, Montréal, QC, Canada4Division of Geriatric Psychiatry, Harvard Medical School, McLean Hospital, Cambridge, MA, United StatesBackgroundLate-life depression (LLD) affects up to 18% of older adults and has been linked to elevated dementia risk. Mindfulness-based cognitive therapy (MBCT) holds promise for treating symptoms of depression and ameliorating cognitive deficits in older adults. While preliminary findings are promising, a definitive RCT investigating its effects on late life depression and cognition have not yet been conducted. We present a protocol describing a multi-site blinded randomized controlled trial, comparing the effects of MBCT and of an active control, a Health Enhancement Program (HEP), on depressive symptoms, executive functioning, and brain biomarkers of LLD, among several other exploratory outcomes.MethodsTwo-hundred and thirteen (n = 213) patients with LLD will be recruited at various centers in Montreal, QC, Canada. Participants will undergo stratified randomization to either MBCT or HEP intervention groups. We will assess changes in (1) depression severity using the Hamilton Depression Rating Scale (HAM-D17), (2) processing speed and executive functioning, (3) brain biomarkers of LLD (hippocampal volume, default network resting-state functional connectivity and executive network resting-state functional connectivity), and (4) other exploratory physiological and mood-based measures, at baseline (0 weeks), post intervention (8 weeks), and 26 weeks after baseline.DiscussionThe proposed study will assess the clinical potential of MBCT to improve symptoms of depression, as well as examine its impact on cognitive impairments and neurobiological markers, and thus inform its use as a promising adjunct in the treatment of LLD.Clinical trial registrationwww.ClinicalTrials.gov, identifier: NCT05366088.https://www.frontiersin.org/articles/10.3389/fnagi.2022.976636/fulllate-life depressionmindfulnesscognitive functionmemorybehavioral activationexecutive function |
| spellingShingle | Magnus Bein Myriam Lesage Elena Dikaios Mallar Chakravarty Zindel Segal Isabelle Royal Mark Speechley Alessandra Schiavetto Daniel Blumberger Matthew D. Sacchet Joseph Therriault Johanna Gruber Valerie Tourjman Stephane Richard-Devantoy Vasavan Nair Marie-Andrée Bruneau Soham Rej Soham Rej Michael Lifshitz Michael Lifshitz Harmehr Sekhon Harmehr Sekhon Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial Frontiers in Aging Neuroscience late-life depression mindfulness cognitive function memory behavioral activation executive function |
| title | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
| title_full | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
| title_fullStr | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
| title_full_unstemmed | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
| title_short | Mindfulness-based cognitive therapy vs. a health enhancement program for the treatment of late-life depression: Study protocol for a multi-site randomized controlled trial |
| title_sort | mindfulness based cognitive therapy vs a health enhancement program for the treatment of late life depression study protocol for a multi site randomized controlled trial |
| topic | late-life depression mindfulness cognitive function memory behavioral activation executive function |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.976636/full |
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