The neuroanatomy of social trust predicts depression vulnerability
Abstract Trust attitude is a social personality trait linked with the estimation of others’ trustworthiness. Trusting others, however, can have substantial negative effects on mental health, such as the development of depression. Despite significant progress in understanding the neurobiology of trus...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20443-w |
| _version_ | 1811194813032169472 |
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| author | Alan S. R. Fermin Toko Kiyonari Yoshie Matsumoto Haruto Takagishi Yang Li Ryota Kanai Masamichi Sakagami Rei Akaishi Naho Ichikawa Masahiro Takamura Satoshi Yokoyama Maro G. Machizawa Hui-Ling Chan Ayumu Matani Shigeto Yamawaki Go Okada Yasumasa Okamoto Toshio Yamagishi |
| author_facet | Alan S. R. Fermin Toko Kiyonari Yoshie Matsumoto Haruto Takagishi Yang Li Ryota Kanai Masamichi Sakagami Rei Akaishi Naho Ichikawa Masahiro Takamura Satoshi Yokoyama Maro G. Machizawa Hui-Ling Chan Ayumu Matani Shigeto Yamawaki Go Okada Yasumasa Okamoto Toshio Yamagishi |
| author_sort | Alan S. R. Fermin |
| collection | DOAJ |
| description | Abstract Trust attitude is a social personality trait linked with the estimation of others’ trustworthiness. Trusting others, however, can have substantial negative effects on mental health, such as the development of depression. Despite significant progress in understanding the neurobiology of trust, whether the neuroanatomy of trust is linked with depression vulnerability remains unknown. To investigate a link between the neuroanatomy of trust and depression vulnerability, we assessed trust and depressive symptoms and employed neuroimaging to acquire brain structure data of healthy participants. A high depressive symptom score was used as an indicator of depression vulnerability. The neuroanatomical results observed with the healthy sample were validated in a sample of clinically diagnosed depressive patients. We found significantly higher depressive symptoms among low trusters than among high trusters. Neuroanatomically, low trusters and depressive patients showed similar volume reduction in brain regions implicated in social cognition, including the dorsolateral prefrontal cortex (DLPFC), dorsomedial PFC, posterior cingulate, precuneus, and angular gyrus. Furthermore, the reduced volume of the DLPFC and precuneus mediated the relationship between trust and depressive symptoms. These findings contribute to understanding social- and neural-markers of depression vulnerability and may inform the development of social interventions to prevent pathological depression. |
| first_indexed | 2024-04-12T00:33:49Z |
| format | Article |
| id | doaj.art-1e06cc08f5234c34aa20592eaf6e91e8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T00:33:49Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1e06cc08f5234c34aa20592eaf6e91e82022-12-22T03:55:14ZengNature PortfolioScientific Reports2045-23222022-10-0112111410.1038/s41598-022-20443-wThe neuroanatomy of social trust predicts depression vulnerabilityAlan S. R. Fermin0Toko Kiyonari1Yoshie Matsumoto2Haruto Takagishi3Yang Li4Ryota Kanai5Masamichi Sakagami6Rei Akaishi7Naho Ichikawa8Masahiro Takamura9Satoshi Yokoyama10Maro G. Machizawa11Hui-Ling Chan12Ayumu Matani13Shigeto Yamawaki14Go Okada15Yasumasa Okamoto16Toshio Yamagishi17Center for Brain, Mind and Kansei Sciences Research, Hiroshima UniversitySchool of Social Informatics, Aoyama Gakuin UniversityBrain Science Institute, Tamagawa UniversityBrain Science Institute, Tamagawa UniversityBrain Science Institute, Tamagawa UniversityDepartment of Neuroinformatics, Araya Inc.Brain Science Institute, Tamagawa UniversitySocial Value Decision Making Unit, Riken Center for Brain ScienceCenter for Brain, Mind and Kansei Sciences Research, Hiroshima UniversityCenter for Brain, Mind and Kansei Sciences Research, Hiroshima UniversityDepartment of Psychiatry and Neurosciences, Hiroshima UniversityCenter for Brain, Mind and Kansei Sciences Research, Hiroshima UniversityCenter for Brain, Mind and Kansei Sciences Research, Hiroshima UniversityCenter for Brain, Mind and Kansei Sciences Research, Hiroshima UniversityCenter for Brain, Mind and Kansei Sciences Research, Hiroshima UniversityDepartment of Psychiatry and Neurosciences, Hiroshima UniversityDepartment of Psychiatry and Neurosciences, Hiroshima UniversityBrain Science Institute, Tamagawa UniversityAbstract Trust attitude is a social personality trait linked with the estimation of others’ trustworthiness. Trusting others, however, can have substantial negative effects on mental health, such as the development of depression. Despite significant progress in understanding the neurobiology of trust, whether the neuroanatomy of trust is linked with depression vulnerability remains unknown. To investigate a link between the neuroanatomy of trust and depression vulnerability, we assessed trust and depressive symptoms and employed neuroimaging to acquire brain structure data of healthy participants. A high depressive symptom score was used as an indicator of depression vulnerability. The neuroanatomical results observed with the healthy sample were validated in a sample of clinically diagnosed depressive patients. We found significantly higher depressive symptoms among low trusters than among high trusters. Neuroanatomically, low trusters and depressive patients showed similar volume reduction in brain regions implicated in social cognition, including the dorsolateral prefrontal cortex (DLPFC), dorsomedial PFC, posterior cingulate, precuneus, and angular gyrus. Furthermore, the reduced volume of the DLPFC and precuneus mediated the relationship between trust and depressive symptoms. These findings contribute to understanding social- and neural-markers of depression vulnerability and may inform the development of social interventions to prevent pathological depression.https://doi.org/10.1038/s41598-022-20443-w |
| spellingShingle | Alan S. R. Fermin Toko Kiyonari Yoshie Matsumoto Haruto Takagishi Yang Li Ryota Kanai Masamichi Sakagami Rei Akaishi Naho Ichikawa Masahiro Takamura Satoshi Yokoyama Maro G. Machizawa Hui-Ling Chan Ayumu Matani Shigeto Yamawaki Go Okada Yasumasa Okamoto Toshio Yamagishi The neuroanatomy of social trust predicts depression vulnerability Scientific Reports |
| title | The neuroanatomy of social trust predicts depression vulnerability |
| title_full | The neuroanatomy of social trust predicts depression vulnerability |
| title_fullStr | The neuroanatomy of social trust predicts depression vulnerability |
| title_full_unstemmed | The neuroanatomy of social trust predicts depression vulnerability |
| title_short | The neuroanatomy of social trust predicts depression vulnerability |
| title_sort | neuroanatomy of social trust predicts depression vulnerability |
| url | https://doi.org/10.1038/s41598-022-20443-w |
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