Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort study
ObjectivesWe aimed to identify the weight gain patterns of small-for-gestational age (SGA) infants in early life and to explore the predictive value for later overweight/obesity in childhood.MethodsWe obtained data from a prospective cohort including term SGA infants born between January 2006 and No...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1030216/full |
| _version_ | 1811319080201748480 |
|---|---|
| author | Ping Li Ping Li You Lu You Lu Di Qie Di Qie Ling Feng Ling Feng Guoqian He Guoqian He Sufei Yang Sufei Yang Fan Yang Fan Yang |
| author_facet | Ping Li Ping Li You Lu You Lu Di Qie Di Qie Ling Feng Ling Feng Guoqian He Guoqian He Sufei Yang Sufei Yang Fan Yang Fan Yang |
| author_sort | Ping Li |
| collection | DOAJ |
| description | ObjectivesWe aimed to identify the weight gain patterns of small-for-gestational age (SGA) infants in early life and to explore the predictive value for later overweight/obesity in childhood.MethodsWe obtained data from a prospective cohort including term SGA infants born between January 2006 and November 2015 who received regular health care from birth to 5 years in West China Second University Hospital, Chengdu, China. A latent class growth analysis (LCGA) was applied to group children with similar growth trajectory patterns. Multiple logistic regression was performed to examine the association between weight gain patterns and later overweight/obesity.ResultsA total of 296 term SGA infants were finally included. Five weight gain trajectories were identified, including excessive rapid catch-up growth (ERCG) (class 1, 10.9%), rapid catch-up growth (RCG) (class 2, 17.9%), appropriate catch-up growth (ACG) (class 3, 53.0%), slow catch-up growth (SCG) (class 4, 13.4%) and almost no catch growth (NCG) (class 5, 4.8%). SGA infants in class 1 and class 2 had a higher BMI according to age- and sex-specific Z scores from 2–5 years of age. In addition, 25% of SGA infants in class 1 and 13.2% of SGA infants in class 2 were found to be overweight/obese at 2-5 years of age. After adjusting for confounders, we found that extremely rapid weight gain (class 1) in the first 2 years of life increased the risk of overweight/obesity by 2.1 times at 2 to 5 years of age (aOR=2.1, 95% CI: 1.3~4.8; P<0.05). Furthermore, the increment of ΔWAZ between 0 and 4 mo was prominently related to the risk of overweight/obesity at 2 to 5 years for term SGA infants (aOR=3.2, 95% CI: 1.7~8.1; P<0.001). A receiver operating characteristic (ROC) curve showed the area under curve (AUC) was 0.7, with a 95% confidence interval (CI) from 0.6 to 0.8 (P<0.001).ConclusionsThe extremely rapid weight gain pattern of term SGA infants in the first 2 years of life increased the risk of overweight/obesity at 2 to 5 years of age. It suggests monitoring weight gain across the infant period represents a first step towards primary prevention of childhood obesity. |
| first_indexed | 2024-04-13T12:36:05Z |
| format | Article |
| id | doaj.art-1e06e07f24464113a15a5f1fd858b3bb |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T12:36:05Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1e06e07f24464113a15a5f1fd858b3bb2022-12-22T02:46:38ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10302161030216Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort studyPing Li0Ping Li1You Lu2You Lu3Di Qie4Di Qie5Ling Feng6Ling Feng7Guoqian He8Guoqian He9Sufei Yang10Sufei Yang11Fan Yang12Fan Yang13Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, Chengdu, ChinaObjectivesWe aimed to identify the weight gain patterns of small-for-gestational age (SGA) infants in early life and to explore the predictive value for later overweight/obesity in childhood.MethodsWe obtained data from a prospective cohort including term SGA infants born between January 2006 and November 2015 who received regular health care from birth to 5 years in West China Second University Hospital, Chengdu, China. A latent class growth analysis (LCGA) was applied to group children with similar growth trajectory patterns. Multiple logistic regression was performed to examine the association between weight gain patterns and later overweight/obesity.ResultsA total of 296 term SGA infants were finally included. Five weight gain trajectories were identified, including excessive rapid catch-up growth (ERCG) (class 1, 10.9%), rapid catch-up growth (RCG) (class 2, 17.9%), appropriate catch-up growth (ACG) (class 3, 53.0%), slow catch-up growth (SCG) (class 4, 13.4%) and almost no catch growth (NCG) (class 5, 4.8%). SGA infants in class 1 and class 2 had a higher BMI according to age- and sex-specific Z scores from 2–5 years of age. In addition, 25% of SGA infants in class 1 and 13.2% of SGA infants in class 2 were found to be overweight/obese at 2-5 years of age. After adjusting for confounders, we found that extremely rapid weight gain (class 1) in the first 2 years of life increased the risk of overweight/obesity by 2.1 times at 2 to 5 years of age (aOR=2.1, 95% CI: 1.3~4.8; P<0.05). Furthermore, the increment of ΔWAZ between 0 and 4 mo was prominently related to the risk of overweight/obesity at 2 to 5 years for term SGA infants (aOR=3.2, 95% CI: 1.7~8.1; P<0.001). A receiver operating characteristic (ROC) curve showed the area under curve (AUC) was 0.7, with a 95% confidence interval (CI) from 0.6 to 0.8 (P<0.001).ConclusionsThe extremely rapid weight gain pattern of term SGA infants in the first 2 years of life increased the risk of overweight/obesity at 2 to 5 years of age. It suggests monitoring weight gain across the infant period represents a first step towards primary prevention of childhood obesity.https://www.frontiersin.org/articles/10.3389/fendo.2022.1030216/fullinfantchidhoodsmall-for-gestational-ageobesityweight gain |
| spellingShingle | Ping Li Ping Li You Lu You Lu Di Qie Di Qie Ling Feng Ling Feng Guoqian He Guoqian He Sufei Yang Sufei Yang Fan Yang Fan Yang Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort study Frontiers in Endocrinology infant chidhood small-for-gestational-age obesity weight gain |
| title | Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort study |
| title_full | Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort study |
| title_fullStr | Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort study |
| title_full_unstemmed | Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort study |
| title_short | Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort study |
| title_sort | early life weight gain patterns of term small for gestational age infants and the predictive ability for later childhood overweight obesity a prospective cohort study |
| topic | infant chidhood small-for-gestational-age obesity weight gain |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1030216/full |
| work_keys_str_mv | AT pingli earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT pingli earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT youlu earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT youlu earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT diqie earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT diqie earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT lingfeng earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT lingfeng earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT guoqianhe earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT guoqianhe earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT sufeiyang earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT sufeiyang earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT fanyang earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy AT fanyang earlylifeweightgainpatternsoftermsmallforgestationalageinfantsandthepredictiveabilityforlaterchildhoodoverweightobesityaprospectivecohortstudy |