Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats
Miao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1019205/full |
| _version_ | 1798045091125788672 |
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| author | Qin Yuan Qianqian Zhou Nanlan Wang Yuancui Zheng Hua Hu Shiyao Hu Huiqun Wang Huiqun Wang |
| author_facet | Qin Yuan Qianqian Zhou Nanlan Wang Yuancui Zheng Hua Hu Shiyao Hu Huiqun Wang Huiqun Wang |
| author_sort | Qin Yuan |
| collection | DOAJ |
| description | Miao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this study, we analyzed the mechanism of action of MSS to prevent simple obesity induced by high-fat diet by proteomics and metabolomics. Quantitative proteomics with tandem mass tagging labeling and liquid chromatography-mass spectrometry was used to analyze the changes of liver proteins and metabolites after the MSS intervention. MSS intervention upregulated 33 proteins and 9 metabolites and downregulated 19 proteins and 10 metabolites. Bioinformatics analysis showed that MSS could prevent simple obesity by acting on the PPAR signaling pathway, retinol metabolism, fatty acid β-oxidation, fatty acid degradation, fatty acid biosynthesis, glycine, serine and threonine metabolism, pyruvate metabolism, citrate cycle (TCA cycle) and other signaling pathways. This study provides new insights into the use of MSS to prevent simple obesity caused by high-fat diets and the search for healthy eating patterns with MSS. |
| first_indexed | 2024-04-11T23:16:14Z |
| format | Article |
| id | doaj.art-1e08442df984468aa153ee4a50f9c984 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T23:16:14Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-1e08442df984468aa153ee4a50f9c9842022-12-22T03:57:37ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.10192051019205Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese ratsQin Yuan0Qianqian Zhou1Nanlan Wang2Yuancui Zheng3Hua Hu4Shiyao Hu5Huiqun Wang6Huiqun Wang7School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaSchool of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, ChinaGuizhou Food Nutrition and Health Engineering Research Center, Guiyang, ChinaMiao Sour Soup (MSS) is a fermented product from the Qiandongnan region of Guizhou Province, which enrich many beneficial ingredients and is widely consumed in the whole China. Fermented food is beneficial to physical health with the potential positive regulating affection on simple obesity. In this study, we analyzed the mechanism of action of MSS to prevent simple obesity induced by high-fat diet by proteomics and metabolomics. Quantitative proteomics with tandem mass tagging labeling and liquid chromatography-mass spectrometry was used to analyze the changes of liver proteins and metabolites after the MSS intervention. MSS intervention upregulated 33 proteins and 9 metabolites and downregulated 19 proteins and 10 metabolites. Bioinformatics analysis showed that MSS could prevent simple obesity by acting on the PPAR signaling pathway, retinol metabolism, fatty acid β-oxidation, fatty acid degradation, fatty acid biosynthesis, glycine, serine and threonine metabolism, pyruvate metabolism, citrate cycle (TCA cycle) and other signaling pathways. This study provides new insights into the use of MSS to prevent simple obesity caused by high-fat diets and the search for healthy eating patterns with MSS.https://www.frontiersin.org/articles/10.3389/fnut.2022.1019205/fullSour Soupobesityproteomicsmetabolomicslipids |
| spellingShingle | Qin Yuan Qianqian Zhou Nanlan Wang Yuancui Zheng Hua Hu Shiyao Hu Huiqun Wang Huiqun Wang Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats Frontiers in Nutrition Sour Soup obesity proteomics metabolomics lipids |
| title | Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats |
| title_full | Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats |
| title_fullStr | Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats |
| title_full_unstemmed | Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats |
| title_short | Integrative proteomics and metabolomics of Guizhou Miao Sour Soup affecting simple obese rats |
| title_sort | integrative proteomics and metabolomics of guizhou miao sour soup affecting simple obese rats |
| topic | Sour Soup obesity proteomics metabolomics lipids |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1019205/full |
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