Hyperosmolarity disrupts tight junction via TNF-α/MMP pathway in primary human corneal epithelial cells

Hyperosmolarity disrupts tight junction via TNF-α/MMP pathway in primary human corneal epithelial cells

AIM: To investigate the mechanism of the tight junction (TJ) disruption and the association between tumor necrosis factor (TNF)-α and matrix metalloproteinase (MMPs) under hyperosmotic condition in primary human corneal epithelial cells (HCECs). METHODS: The cultured HCECs were exposed to media whic...

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Bibliographic Details
Main Authors: Yun Zhang, Ming Yang, Shi-Xin Zhao, Li Nie, Li-Jun Shen, Wei Han
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2022-05-01
Series:International Journal of Ophthalmology
Subjects:
dry eye
hyperosmolarity
cornea epithelium
tight junction
Online Access:http://ies.ijo.cn/en_publish/2022/5/20220501.pdf

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