3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1<i>H</i>-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents

3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1<i>H</i>-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents

Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a triazole moiety. This tryptamine was used in...

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Bibliographic Details
Main Authors: João L. P. Ribeiro, Joana B. Loureiro, Susana M. M. Lopes, Lucília Saraiva, Teresa M. V. D. Pinho e Melo
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceuticals
Subjects:
β-carbolines
anticancer agents
triazoles
tetrazoles
nitrosoalkenes
hetero-Diels–Alder reaction
Online Access:https://www.mdpi.com/1424-8247/15/12/1510

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