High type I collagen density fails to increase breast cancer stem cell phenotype

High type I collagen density fails to increase breast cancer stem cell phenotype

Breast cancer is a highly frequent and lethal malignancy which metastasis and relapse frequently associates with the existence of breast cancer stem cells (CSCs). CSCs are undifferentiated, aggressive and highly resistant to therapy, with traits modulated by microenvironmental cells and the extracel...

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Bibliographic Details
Main Authors: Iuri C. Valadão, Ana Carolina L. Ralph, François Bordeleau, Luciana M. Dzik, Karen S.C. Borbely, Murilo V. Geraldo, Cynthia A. Reinhart-King, Vanessa M. Freitas
Format: Article
Language:English
Published: PeerJ Inc. 2020-05-01
Series:PeerJ
Subjects:
Breast cancer
Cancer stem cells
Type I collagen
Mechanotransduction
Extracellular matrix
Online Access:https://peerj.com/articles/9153.pdf

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