The impact of aging and physical training on angiogenesis in the musculoskeletal system
Angiogenesis is the physiological process of capillary growth. It is strictly regulated by the balanced activity of agents that promote the formation of capillaries (pro-angiogenic factors) on the one hand and inhibit their growth on the other hand (anti-angiogenic factors). Capillary rarefaction an...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2022-11-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/14228.pdf |
| _version_ | 1797421029440618496 |
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| author | Magdalena Zmudzka Jerzy A. Zoladz Joanna Majerczak |
| author_facet | Magdalena Zmudzka Jerzy A. Zoladz Joanna Majerczak |
| author_sort | Magdalena Zmudzka |
| collection | DOAJ |
| description | Angiogenesis is the physiological process of capillary growth. It is strictly regulated by the balanced activity of agents that promote the formation of capillaries (pro-angiogenic factors) on the one hand and inhibit their growth on the other hand (anti-angiogenic factors). Capillary rarefaction and insufficient angiogenesis are some of the main causes that limit blood flow during aging, whereas physical training is a potent non-pharmacological method to intensify capillary growth in the musculoskeletal system. The main purpose of this study is to present the current state of knowledge concerning the key signalling molecules implicated in the regulation of skeletal muscle and bone angiogenesis during aging and physical training. |
| first_indexed | 2024-03-09T07:11:03Z |
| format | Article |
| id | doaj.art-1e0e980637a94b3f9fe4d916dcdde15b |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:11:03Z |
| publishDate | 2022-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-1e0e980637a94b3f9fe4d916dcdde15b2023-12-03T09:06:46ZengPeerJ Inc.PeerJ2167-83592022-11-0110e1422810.7717/peerj.14228The impact of aging and physical training on angiogenesis in the musculoskeletal systemMagdalena Zmudzka0Jerzy A. Zoladz1Joanna Majerczak2Chair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, PolandChair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, PolandChair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, PolandAngiogenesis is the physiological process of capillary growth. It is strictly regulated by the balanced activity of agents that promote the formation of capillaries (pro-angiogenic factors) on the one hand and inhibit their growth on the other hand (anti-angiogenic factors). Capillary rarefaction and insufficient angiogenesis are some of the main causes that limit blood flow during aging, whereas physical training is a potent non-pharmacological method to intensify capillary growth in the musculoskeletal system. The main purpose of this study is to present the current state of knowledge concerning the key signalling molecules implicated in the regulation of skeletal muscle and bone angiogenesis during aging and physical training.https://peerj.com/articles/14228.pdfAngiogenesisPhysical trainingMuscle-bone crosstalkSkeletal muscle agingBone agingNitric oxide |
| spellingShingle | Magdalena Zmudzka Jerzy A. Zoladz Joanna Majerczak The impact of aging and physical training on angiogenesis in the musculoskeletal system PeerJ Angiogenesis Physical training Muscle-bone crosstalk Skeletal muscle aging Bone aging Nitric oxide |
| title | The impact of aging and physical training on angiogenesis in the musculoskeletal system |
| title_full | The impact of aging and physical training on angiogenesis in the musculoskeletal system |
| title_fullStr | The impact of aging and physical training on angiogenesis in the musculoskeletal system |
| title_full_unstemmed | The impact of aging and physical training on angiogenesis in the musculoskeletal system |
| title_short | The impact of aging and physical training on angiogenesis in the musculoskeletal system |
| title_sort | impact of aging and physical training on angiogenesis in the musculoskeletal system |
| topic | Angiogenesis Physical training Muscle-bone crosstalk Skeletal muscle aging Bone aging Nitric oxide |
| url | https://peerj.com/articles/14228.pdf |
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