Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
Abstract Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia inducible factor 1 subunit alpha (HI...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-023-01750-w |
| _version_ | 1827985023254396928 |
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| author | A. Katharina Ceranski Martha J. Carreño-Gonzalez Anna C. Ehlers Maria Vittoria Colombo Florencia Cidre-Aranaz Thomas G. P. Grünewald |
| author_facet | A. Katharina Ceranski Martha J. Carreño-Gonzalez Anna C. Ehlers Maria Vittoria Colombo Florencia Cidre-Aranaz Thomas G. P. Grünewald |
| author_sort | A. Katharina Ceranski |
| collection | DOAJ |
| description | Abstract Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is the principal molecular mediator of the hypoxic response in cancer whereas EWSR1::FLI1 constitutes the oncogenic driver of EwS. Interaction of the two proteins has been shown in EwS. Although a growing body of studies investigated hypoxia and HIFs in EwS, their precise role for EwS pathophysiology is not clarified to date. This review summarizes and structures recent findings demonstrating that hypoxia and HIFs play a role in EwS at multiple levels. We propose to view hypoxia and HIFs as independent protagonists in the story of EwS and give a perspective on their potential clinical relevance as prognostic markers and therapeutic targets in EwS treatment. |
| first_indexed | 2024-04-09T23:07:07Z |
| format | Article |
| id | doaj.art-1e0ec40abe78487a8e5714fd7e4561d0 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-04-09T23:07:07Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-1e0ec40abe78487a8e5714fd7e4561d02023-03-22T10:35:12ZengBMCMolecular Cancer1476-45982023-03-0122111510.1186/s12943-023-01750-wHypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationshipA. Katharina Ceranski0Martha J. Carreño-Gonzalez1Anna C. Ehlers2Maria Vittoria Colombo3Florencia Cidre-Aranaz4Thomas G. P. Grünewald5Hopp-Children’s Cancer Center (KiTZ)Hopp-Children’s Cancer Center (KiTZ)Hopp-Children’s Cancer Center (KiTZ)Hopp-Children’s Cancer Center (KiTZ)Hopp-Children’s Cancer Center (KiTZ)Hopp-Children’s Cancer Center (KiTZ)Abstract Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is the principal molecular mediator of the hypoxic response in cancer whereas EWSR1::FLI1 constitutes the oncogenic driver of EwS. Interaction of the two proteins has been shown in EwS. Although a growing body of studies investigated hypoxia and HIFs in EwS, their precise role for EwS pathophysiology is not clarified to date. This review summarizes and structures recent findings demonstrating that hypoxia and HIFs play a role in EwS at multiple levels. We propose to view hypoxia and HIFs as independent protagonists in the story of EwS and give a perspective on their potential clinical relevance as prognostic markers and therapeutic targets in EwS treatment.https://doi.org/10.1186/s12943-023-01750-wEwing sarcomahypoxiaHIF-1-aHIF-1-bARNT |
| spellingShingle | A. Katharina Ceranski Martha J. Carreño-Gonzalez Anna C. Ehlers Maria Vittoria Colombo Florencia Cidre-Aranaz Thomas G. P. Grünewald Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship Molecular Cancer Ewing sarcoma hypoxia HIF-1-a HIF-1-b ARNT |
| title | Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship |
| title_full | Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship |
| title_fullStr | Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship |
| title_full_unstemmed | Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship |
| title_short | Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship |
| title_sort | hypoxia and hifs in ewing sarcoma new perspectives on a multi facetted relationship |
| topic | Ewing sarcoma hypoxia HIF-1-a HIF-1-b ARNT |
| url | https://doi.org/10.1186/s12943-023-01750-w |
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