Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

Abstract Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia inducible factor 1 subunit alpha (HI...

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Bibliographic Details
Main Authors:	A. Katharina Ceranski, Martha J. Carreño-Gonzalez, Anna C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz, Thomas G. P. Grünewald
Format:	Article
Language:	English
Published:	BMC 2023-03-01
Series:	Molecular Cancer
Subjects:	Ewing sarcoma hypoxia HIF-1-a HIF-1-b ARNT
Online Access:	https://doi.org/10.1186/s12943-023-01750-w

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