Evaluation of the Efficacy of Antihelminthic Treatment with Oxantel-Pyrantel Pamoate and Reinfection by Geohelminths, in Children from two Populations in Sucre State
Efficacy of oxantel-pyrantel pamoate and helminthic reinfection were evaluated in children from both sexes between the ages of 3 and 14. We selected 289 children in total, 123 from Agua Blanca, Montes Municipality, and 166 from Malariologia, Cumana, Sucre Municipality. Feces samples were collected a...
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| Format: | Article |
| Language: | English |
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2005-08-01
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| Series: | Kasmera |
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| Online Access: | https://produccioncientificaluz.org/index.php/kasmera/article/view/4759 |
| _version_ | 1797727766720806912 |
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| author | Denice Patete Elvia Michelli Marcos De Donato |
| author_facet | Denice Patete Elvia Michelli Marcos De Donato |
| author_sort | Denice Patete |
| collection | DOAJ |
| description | Efficacy of oxantel-pyrantel pamoate and helminthic reinfection were evaluated in children from both sexes between the ages of 3 and 14. We selected 289 children in total, 123 from Agua Blanca, Montes Municipality, and 166 from Malariologia, Cumana, Sucre Municipality. Feces samples were collected and freshly processed by a coproparasitologic analysis with saline solution and lugol, using also the methods of Ritchie, feces culture in agar plates, quantitative Kato-Katz and quantification of protozoan. Four post treatment samples were taken from each individual (weeks 1, 3, 5 and 10). The findings were presented in prevalencia charts; the tests of squared Ji (c2) and ANOVAmultiple, to 95% of dependability, were also applied, and classical methods were used to determine the efficacy and effectiveness of the drug, and helminthic reinfection. The prevalence of intestinal parasites was 99.19% for Agua Blanca and 85.54% for Malariologia. Trichuris trichiura was the most prevalent helminth in both populations (74.84% and 50.00%, respectively), and Blastocystis hominis was the most prevalent protozoan (73.17% and 40.96%, respectively). Most of the helminthic infections showed low levels and no statistically significant differences were seen between the populations (F=2,76; p>0,05 for Ascaris lumbricoides, F=2,13; p>0,05 for T. trichiura and F=1,17;p>0,05 for Necator americanus). Children between 7 and 10 years old were the most affected. Oxantel-pyrantel pamoate showed more efficacy and effectiveness towards A. lumbricoides than any other helminthic species. There were statistical differences in the reinfections between the two populations (C2=14,82; p>0,05). Environmental characteristics of each community could favor helminthic transmission and maintain the infection-reinfection cycle seen. |
| first_indexed | 2024-03-12T11:04:10Z |
| format | Article |
| id | doaj.art-1e0fef394bc3462c95746b3894ad4b46 |
| institution | Directory Open Access Journal |
| issn | 0075-5222 2477-9628 |
| language | English |
| last_indexed | 2024-03-12T11:04:10Z |
| publishDate | 2005-08-01 |
| publisher | Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
| record_format | Article |
| series | Kasmera |
| spelling | doaj.art-1e0fef394bc3462c95746b3894ad4b462023-09-02T04:17:05ZengUniversidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y TropicalesKasmera0075-52222477-96282005-08-0133214215424306Evaluation of the Efficacy of Antihelminthic Treatment with Oxantel-Pyrantel Pamoate and Reinfection by Geohelminths, in Children from two Populations in Sucre StateDenice Patete0Elvia Michelli1Marcos De Donato2Cátedra de Bacteriología Clínica, Departamento de Bioanálisis, Escuela de ciencias. Núcleo de Sucre. Universidad de Oriente.Cátedra de Bacteriología Clínica, Departamento de Bioanálisis, Escuela de ciencias. Núcleo de Sucre. Universidad de Oriente.Instituto de Investigación en Biomedicina y Ciencias Aplicadas. Núcleo de Sucre. Universidad de Oriente. Núcleo de Sucre. Universidad de Oriente.Efficacy of oxantel-pyrantel pamoate and helminthic reinfection were evaluated in children from both sexes between the ages of 3 and 14. We selected 289 children in total, 123 from Agua Blanca, Montes Municipality, and 166 from Malariologia, Cumana, Sucre Municipality. Feces samples were collected and freshly processed by a coproparasitologic analysis with saline solution and lugol, using also the methods of Ritchie, feces culture in agar plates, quantitative Kato-Katz and quantification of protozoan. Four post treatment samples were taken from each individual (weeks 1, 3, 5 and 10). The findings were presented in prevalencia charts; the tests of squared Ji (c2) and ANOVAmultiple, to 95% of dependability, were also applied, and classical methods were used to determine the efficacy and effectiveness of the drug, and helminthic reinfection. The prevalence of intestinal parasites was 99.19% for Agua Blanca and 85.54% for Malariologia. Trichuris trichiura was the most prevalent helminth in both populations (74.84% and 50.00%, respectively), and Blastocystis hominis was the most prevalent protozoan (73.17% and 40.96%, respectively). Most of the helminthic infections showed low levels and no statistically significant differences were seen between the populations (F=2,76; p>0,05 for Ascaris lumbricoides, F=2,13; p>0,05 for T. trichiura and F=1,17;p>0,05 for Necator americanus). Children between 7 and 10 years old were the most affected. Oxantel-pyrantel pamoate showed more efficacy and effectiveness towards A. lumbricoides than any other helminthic species. There were statistical differences in the reinfections between the two populations (C2=14,82; p>0,05). Environmental characteristics of each community could favor helminthic transmission and maintain the infection-reinfection cycle seen.https://produccioncientificaluz.org/index.php/kasmera/article/view/4759Tratamiento antihelmíntico, eficacia, reinfección por geohelmintos |
| spellingShingle | Denice Patete Elvia Michelli Marcos De Donato Evaluation of the Efficacy of Antihelminthic Treatment with Oxantel-Pyrantel Pamoate and Reinfection by Geohelminths, in Children from two Populations in Sucre State Kasmera Tratamiento antihelmíntico, eficacia, reinfección por geohelmintos |
| title | Evaluation of the Efficacy of Antihelminthic Treatment with Oxantel-Pyrantel Pamoate and Reinfection by Geohelminths, in Children from two Populations in Sucre State |
| title_full | Evaluation of the Efficacy of Antihelminthic Treatment with Oxantel-Pyrantel Pamoate and Reinfection by Geohelminths, in Children from two Populations in Sucre State |
| title_fullStr | Evaluation of the Efficacy of Antihelminthic Treatment with Oxantel-Pyrantel Pamoate and Reinfection by Geohelminths, in Children from two Populations in Sucre State |
| title_full_unstemmed | Evaluation of the Efficacy of Antihelminthic Treatment with Oxantel-Pyrantel Pamoate and Reinfection by Geohelminths, in Children from two Populations in Sucre State |
| title_short | Evaluation of the Efficacy of Antihelminthic Treatment with Oxantel-Pyrantel Pamoate and Reinfection by Geohelminths, in Children from two Populations in Sucre State |
| title_sort | evaluation of the efficacy of antihelminthic treatment with oxantel pyrantel pamoate and reinfection by geohelminths in children from two populations in sucre state |
| topic | Tratamiento antihelmíntico, eficacia, reinfección por geohelmintos |
| url | https://produccioncientificaluz.org/index.php/kasmera/article/view/4759 |
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