An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS)
Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic...
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| author | Francesca Truzzi Camilla Tibaldi Yanxin Zhang Giovanni Dinelli Eros D′Amen |
| author_facet | Francesca Truzzi Camilla Tibaldi Yanxin Zhang Giovanni Dinelli Eros D′Amen |
| author_sort | Francesca Truzzi |
| collection | DOAJ |
| description | Polyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. This review will provide an overview of the information regarding 10 dietarypolyphenols (ferulic acid, chlorogenic acid, rutin, quercetin, apigenin, cirsimaritin, daidzein, resveratrol, ellagic acid, and curcumin) and their association with the BCS classification. |
| first_indexed | 2024-03-10T11:07:06Z |
| format | Article |
| id | doaj.art-1e12e6a181b144628dd1816beb6e8833 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:07:06Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1e12e6a181b144628dd1816beb6e88332023-11-21T21:03:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211551410.3390/ijms22115514An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS)Francesca Truzzi0Camilla Tibaldi1Yanxin Zhang2Giovanni Dinelli3Eros D′Amen4Department of Agricultural and Food Sciences, Alma Mater Studiorum-University di Bologna, 40127 Bologna, ItalyDepartment of Agricultural and Food Sciences, Alma Mater Studiorum-University di Bologna, 40127 Bologna, ItalyDepartment of Agricultural and Food Sciences, Alma Mater Studiorum-University di Bologna, 40127 Bologna, ItalyDepartment of Agricultural and Food Sciences, Alma Mater Studiorum-University di Bologna, 40127 Bologna, ItalyDepartment of Agricultural and Food Sciences, Alma Mater Studiorum-University di Bologna, 40127 Bologna, ItalyPolyphenols are natural organic compounds produced by plants, acting as antioxidants by reacting with ROS. These compounds are widely consumed in daily diet and many studies report several benefits to human health thanks to their bioavailability in humans. However, the digestion process of phenolic compounds is still not completely clear. Moreover, bioavailability is dependent on the metabolic phase of these compounds. The LogP value can be managed as a simplified measure of the lipophilicity of a substance ingested within the human body, which affects resultant absorption. The biopharmaceutical classification system (BCS), a method used to classify drugs intended for gastrointestinal absorption, correlates the solubility and permeability of the drug with both the rate and extent of oral absorption. BCS may be helpful to measure the bioactive constituents of foods, such as polyphenols, in order to understand their nutraceutical potential. There are many literature studies that focus on permeability, absorption, and bioavailability of polyphenols and their resultant metabolic byproducts, but there is still confusion about their respective LogP values and BCS classification. This review will provide an overview of the information regarding 10 dietarypolyphenols (ferulic acid, chlorogenic acid, rutin, quercetin, apigenin, cirsimaritin, daidzein, resveratrol, ellagic acid, and curcumin) and their association with the BCS classification.https://www.mdpi.com/1422-0067/22/11/5514polyphenolsmetabolismbioavailabilityLogPbiopharmaceutical classification system |
| spellingShingle | Francesca Truzzi Camilla Tibaldi Yanxin Zhang Giovanni Dinelli Eros D′Amen An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS) International Journal of Molecular Sciences polyphenols metabolism bioavailability LogP biopharmaceutical classification system |
| title | An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS) |
| title_full | An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS) |
| title_fullStr | An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS) |
| title_full_unstemmed | An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS) |
| title_short | An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS) |
| title_sort | overview on dietary polyphenols and their biopharmaceutical classification system bcs |
| topic | polyphenols metabolism bioavailability LogP biopharmaceutical classification system |
| url | https://www.mdpi.com/1422-0067/22/11/5514 |
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