Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens<sup>†</sup>. This article is dedicated to the memory of Pierrick Thoraval (1960–2000).
<p>Abstract</p> <p>Selection for disease resistance related traits is a tool of choice for evidencing and exploring genetic variability and studying underlying resistance mechanisms. In this framework, chickens originating from a base population, homozygote for the <it>B</...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
BMC
2004-01-01
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| Series: | Genetics Selection Evolution |
| Subjects: | |
| Online Access: | http://www.gsejournal.org/content/36/1/65 |
| Summary: | <p>Abstract</p> <p>Selection for disease resistance related traits is a tool of choice for evidencing and exploring genetic variability and studying underlying resistance mechanisms. In this framework, chickens originating from a base population, homozygote for the <it>B</it><sup>19 </sup>major histocompatibility complex (MHC) were divergently selected for either progression or regression of tumors induced at 4 weeks of age by a SR-D strain of Rous sarcoma virus (RSV). The first generation of selection was based on a progeny test and subsequent selections were performed on full-sibs. Data of 18 generations including a total of 2010 birds measured were analyzed for the tumor profile index (TPI), a synthetic criterion of resistance derived from recording the volume of the tumors and mortality. Response to selection and heritability of TPI were estimated using a restricted maximum likelihood method with an animal model. Significant progress was shown in both directions: the lines differing significantly for TPI and mortality becoming null in the "regressor" line. Heritability of TPI was estimated as 0.49 ± 0.05 and 0.53 ± 0.06 within the progressor and regressor lines respectively, and 0.46 ± 0.03 when estimated over lines. Preliminary results showed within the progressor line a possible association between one <it>Rfp-Y </it>type and the growth of tumors.</p> |
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| ISSN: | 0999-193X 1297-9686 |