Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats
Aim: The aim of this study was to investigate the involvement of peroxisome proliferator-activated receptor gamma (PPAR-γ) in renal protection offered by sinapic acid in cisplatin-induced nephrotoxicity in male rats. Materials and Methods: Nephrotoxicity was induced by single dose of cisplatin (5 mg...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=2;spage=146;epage=154;aulast=Singh |
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| author | Hardevinder Pal Singh Thakur Gurjeet Singh Randhir Singh |
| author_facet | Hardevinder Pal Singh Thakur Gurjeet Singh Randhir Singh |
| author_sort | Hardevinder Pal Singh |
| collection | DOAJ |
| description | Aim: The aim of this study was to investigate the involvement of peroxisome proliferator-activated receptor gamma (PPAR-γ) in renal protection offered by sinapic acid in cisplatin-induced nephrotoxicity in male rats. Materials and Methods: Nephrotoxicity was induced by single dose of cisplatin (5 mg/kg, intraperitoneal [i.p.]) in rats. Cisplatin-induced nephrotoxicity was assessed by measuring serum creatinine, creatinine clearance, urea, uric acid, potassium, magnesium levels, fractional excretion of sodium, and microproteinuria in rats. Superoxide anion generation, thiobarbituric acid reactive substances, myeloperoxidase activity, and reduced glutathione levels were measured to assess oxidative stress in renal tissues. Hematoxylin and eosin stain showed renal histological changes. Results: The significant changes in serum and urinary parameters, elevated oxidative stress, and renal histological changes established the induction of nephrotoxicity. Sinapic acid treatment (20 and 40 mg/kg, orally [p.o.]) provides dose-dependent and significant (P < 0.05) nephroprotection against cisplatin-mediated nephrotoxicity in rats. Nephroprotective effect of sinapic acid was abolished by PPAR-γ inhibitor, bisphenol A diglycidyl ether (30 mg/kg, i.p.) in rats. Conclusion: It is concluded that PPAR-γ agonism serves as one of the mechanisms in sinapic acid-mediated renoprotection. |
| first_indexed | 2024-12-14T08:21:27Z |
| format | Article |
| id | doaj.art-1e150a4be6034f22bbf00e2cb999247c |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-12-14T08:21:27Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-1e150a4be6034f22bbf00e2cb999247c2022-12-21T23:09:47ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062020-01-0112214615410.4103/jpbs.JPBS_220_19Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in ratsHardevinder Pal SinghThakur Gurjeet SinghRandhir SinghAim: The aim of this study was to investigate the involvement of peroxisome proliferator-activated receptor gamma (PPAR-γ) in renal protection offered by sinapic acid in cisplatin-induced nephrotoxicity in male rats. Materials and Methods: Nephrotoxicity was induced by single dose of cisplatin (5 mg/kg, intraperitoneal [i.p.]) in rats. Cisplatin-induced nephrotoxicity was assessed by measuring serum creatinine, creatinine clearance, urea, uric acid, potassium, magnesium levels, fractional excretion of sodium, and microproteinuria in rats. Superoxide anion generation, thiobarbituric acid reactive substances, myeloperoxidase activity, and reduced glutathione levels were measured to assess oxidative stress in renal tissues. Hematoxylin and eosin stain showed renal histological changes. Results: The significant changes in serum and urinary parameters, elevated oxidative stress, and renal histological changes established the induction of nephrotoxicity. Sinapic acid treatment (20 and 40 mg/kg, orally [p.o.]) provides dose-dependent and significant (P < 0.05) nephroprotection against cisplatin-mediated nephrotoxicity in rats. Nephroprotective effect of sinapic acid was abolished by PPAR-γ inhibitor, bisphenol A diglycidyl ether (30 mg/kg, i.p.) in rats. Conclusion: It is concluded that PPAR-γ agonism serves as one of the mechanisms in sinapic acid-mediated renoprotection.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=2;spage=146;epage=154;aulast=Singhbisphenol a diglycidyl ethercisplatinnephrotoxicityoxidative stressperoxisome proliferator-activated receptor-gammarenoprotectionsinapic acid |
| spellingShingle | Hardevinder Pal Singh Thakur Gurjeet Singh Randhir Singh Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats Journal of Pharmacy and Bioallied Sciences bisphenol a diglycidyl ether cisplatin nephrotoxicity oxidative stress peroxisome proliferator-activated receptor-gamma renoprotection sinapic acid |
| title | Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats |
| title_full | Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats |
| title_fullStr | Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats |
| title_full_unstemmed | Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats |
| title_short | Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats |
| title_sort | sinapic acid attenuates cisplatin induced nephrotoxicity through peroxisome proliferator activated receptor gamma agonism in rats |
| topic | bisphenol a diglycidyl ether cisplatin nephrotoxicity oxidative stress peroxisome proliferator-activated receptor-gamma renoprotection sinapic acid |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=2;spage=146;epage=154;aulast=Singh |
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