Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications

Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications

Heparin and heparan sulphate (H/HS) are important members of the glycosaminoglycan family of sugars that regulate a substantial number of biological processes. Such biological promiscuity is underpinned by hetereogeneity in their molecular structure. The degree of O-sulfation, particularly at the 6-...

Full description

Bibliographic Details
Main Authors: Marek Baráth, Steen U. Hansen, Charlotte E. Dalton, Gordon C. Jayson, Gavin J. Miller, John M. Gardiner
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Molecules
Subjects:
heparin
oligosaccharide
iduronate
GAG mimetic
Online Access:http://www.mdpi.com/1420-3049/20/4/6167

Similar Items

Similar Items