A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes
The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here the authors show that a super enhancer controls the spatiotemporal expression of the genes at the fast myosin heavy chain locus by DNA looping and that this expression profile is recapitulated...
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Bibliographic Details
| Main Authors: |
Matthieu Dos Santos,
Stéphanie Backer,
Frédéric Auradé,
Matthew Man-Kin Wong,
Maud Wurmser,
Rémi Pierre,
Francina Langa,
Marcio Do Cruzeiro,
Alain Schmitt,
Jean-Paul Concordet,
Athanassia Sotiropoulos,
F. Jeffrey Dilworth,
Daan Noordermeer,
Frédéric Relaix,
Iori Sakakibara,
Pascal Maire |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-28666-1
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