A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes
The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here the authors show that a super enhancer controls the spatiotemporal expression of the genes at the fast myosin heavy chain locus by DNA looping and that this expression profile is recapitulated...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28666-1 |
| _version_ | 1818501187125641216 |
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| author | Matthieu Dos Santos Stéphanie Backer Frédéric Auradé Matthew Man-Kin Wong Maud Wurmser Rémi Pierre Francina Langa Marcio Do Cruzeiro Alain Schmitt Jean-Paul Concordet Athanassia Sotiropoulos F. Jeffrey Dilworth Daan Noordermeer Frédéric Relaix Iori Sakakibara Pascal Maire |
| author_facet | Matthieu Dos Santos Stéphanie Backer Frédéric Auradé Matthew Man-Kin Wong Maud Wurmser Rémi Pierre Francina Langa Marcio Do Cruzeiro Alain Schmitt Jean-Paul Concordet Athanassia Sotiropoulos F. Jeffrey Dilworth Daan Noordermeer Frédéric Relaix Iori Sakakibara Pascal Maire |
| author_sort | Matthieu Dos Santos |
| collection | DOAJ |
| description | The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here the authors show that a super enhancer controls the spatiotemporal expression of the genes at the fast myosin heavy chain locus by DNA looping and that this expression profile is recapitulated in a rainbow transgenic mouse model of the locus. |
| first_indexed | 2024-12-10T20:52:46Z |
| format | Article |
| id | doaj.art-1e1732b409944febbd7c8c1cfe87a24b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T20:52:46Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1e1732b409944febbd7c8c1cfe87a24b2022-12-22T01:34:02ZengNature PortfolioNature Communications2041-17232022-02-0113111710.1038/s41467-022-28666-1A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genesMatthieu Dos Santos0Stéphanie Backer1Frédéric Auradé2Matthew Man-Kin Wong3Maud Wurmser4Rémi Pierre5Francina Langa6Marcio Do Cruzeiro7Alain Schmitt8Jean-Paul Concordet9Athanassia Sotiropoulos10F. Jeffrey Dilworth11Daan Noordermeer12Frédéric Relaix13Iori Sakakibara14Pascal Maire15Université de Paris, Institut Cochin, INSERM, CNRSUniversité de Paris, Institut Cochin, INSERM, CNRSUniv Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRBRegenerative Medicine Program. Ottawa Hospital Research InstituteUniversité de Paris, Institut Cochin, INSERM, CNRSUniversité de Paris, Institut Cochin, INSERM, CNRSInstitut PasteurUniversité de Paris, Institut Cochin, INSERM, CNRSUniversité de Paris, Institut Cochin, INSERM, CNRSMNHNUniversité de Paris, Institut Cochin, INSERM, CNRSRegenerative Medicine Program. Ottawa Hospital Research InstituteUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRBUniversité de Paris, Institut Cochin, INSERM, CNRSUniversité de Paris, Institut Cochin, INSERM, CNRSThe contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here the authors show that a super enhancer controls the spatiotemporal expression of the genes at the fast myosin heavy chain locus by DNA looping and that this expression profile is recapitulated in a rainbow transgenic mouse model of the locus.https://doi.org/10.1038/s41467-022-28666-1 |
| spellingShingle | Matthieu Dos Santos Stéphanie Backer Frédéric Auradé Matthew Man-Kin Wong Maud Wurmser Rémi Pierre Francina Langa Marcio Do Cruzeiro Alain Schmitt Jean-Paul Concordet Athanassia Sotiropoulos F. Jeffrey Dilworth Daan Noordermeer Frédéric Relaix Iori Sakakibara Pascal Maire A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes Nature Communications |
| title | A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes |
| title_full | A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes |
| title_fullStr | A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes |
| title_full_unstemmed | A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes |
| title_short | A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes |
| title_sort | fast myosin super enhancer dictates muscle fiber phenotype through competitive interactions with myosin genes |
| url | https://doi.org/10.1038/s41467-022-28666-1 |
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