Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury
Recent studies have reported that ischemia/reperfusion (I/R) may act in the immune system where an exaggerated inflammatory response is initiated. With the activation of the immune system, damage-associated molecular patterns migrate and adhere to the I/R region, consequently inducing multiorgan inj...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2018;volume=30;issue=2;spage=61;epage=65;aulast=Lin |
| _version_ | 1818229687481008128 |
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| author | Heng Lin Ching-Feng Cheng |
| author_facet | Heng Lin Ching-Feng Cheng |
| author_sort | Heng Lin |
| collection | DOAJ |
| description | Recent studies have reported that ischemia/reperfusion (I/R) may act in the immune system where an exaggerated inflammatory response is initiated. With the activation of the immune system, damage-associated molecular patterns migrate and adhere to the I/R region, consequently inducing multiorgan injury. Emerging data indicate that upon I/R, stress-inducible proteins, including activating transcription factor 3 (ATF3), play essential roles in signaling during antiapoptotic, antimigration, and anti-inflammatory processes. Accumulating data suggest that ATF3 may be a potential target in I/R- or inflammation-induced organ dysfunction. This minireview focuses on the emerging evidence of the roles of ATF3 in multiple organs including the kidney, myocardium, and brain following I/R injury. In addition, this review addresses the role of ATF3 in chronic inflammation-induced pathophysiologies such as diabetes and atherosclerosis. |
| first_indexed | 2024-12-12T10:22:34Z |
| format | Article |
| id | doaj.art-1e17c9e41b2543a3a007f105be2e4077 |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-12-12T10:22:34Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-1e17c9e41b2543a3a007f105be2e40772022-12-22T00:27:32ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562018-01-01302616510.4103/tcmj.tcmj_37_18Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injuryHeng LinChing-Feng ChengRecent studies have reported that ischemia/reperfusion (I/R) may act in the immune system where an exaggerated inflammatory response is initiated. With the activation of the immune system, damage-associated molecular patterns migrate and adhere to the I/R region, consequently inducing multiorgan injury. Emerging data indicate that upon I/R, stress-inducible proteins, including activating transcription factor 3 (ATF3), play essential roles in signaling during antiapoptotic, antimigration, and anti-inflammatory processes. Accumulating data suggest that ATF3 may be a potential target in I/R- or inflammation-induced organ dysfunction. This minireview focuses on the emerging evidence of the roles of ATF3 in multiple organs including the kidney, myocardium, and brain following I/R injury. In addition, this review addresses the role of ATF3 in chronic inflammation-induced pathophysiologies such as diabetes and atherosclerosis.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2018;volume=30;issue=2;spage=61;epage=65;aulast=LinActivating transcription factor 3IschemiaReperfusion |
| spellingShingle | Heng Lin Ching-Feng Cheng Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury Tzu-Chi Medical Journal Activating transcription factor 3 Ischemia Reperfusion |
| title | Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury |
| title_full | Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury |
| title_fullStr | Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury |
| title_full_unstemmed | Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury |
| title_short | Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury |
| title_sort | activating transcription factor 3 an early cellular adaptive responder in ischemia reperfusion induced injury |
| topic | Activating transcription factor 3 Ischemia Reperfusion |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2018;volume=30;issue=2;spage=61;epage=65;aulast=Lin |
| work_keys_str_mv | AT henglin activatingtranscriptionfactor3anearlycellularadaptiveresponderinischemiareperfusioninducedinjury AT chingfengcheng activatingtranscriptionfactor3anearlycellularadaptiveresponderinischemiareperfusioninducedinjury |