Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer’s disease neurodegeneration

Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer’s disease neurodegeneration

Alzheimer’s disease (AD) is the most common form of dementia in the elderly. The vast majority of cases are not linked to a known genetic defect and the molecular mechanisms underlying AD pathogenesis are still elusive. Evidence suggests that mitochondrial dysfunction is a prominent feature of the d...

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Bibliographic Details
Main Authors: Tiziana eCasoli, Liana eSpazzafumo, Giuseppina eDi Stefano, Fiorenzo eConti
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Aging
Mutation
Alzheimer’s disease
mitochondrial DNA
allele
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00142/full

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