Clinical Characteristics, Treatment Outcome and Associated Factors of Epilepsy Among Children at Hospitals of North-West Ethiopia
Mohammed Nasir,1 Ermias Abebaw,2 Muluken Ahmed,3 Daniel Bekele Ketema4 1Pediatrics Department, Hawassa University, Hawassa, Ethiopia; 2Pediatrics Department, ALERT Comprehensive Specialized Hospital, Addis Ababa, Ethiopia; 3Pediatrics Department, Arba Minch University, Arba Minch, Ethiopia; 4Public...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | Pediatric Health, Medicine and Therapeutics |
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| Online Access: | https://www.dovepress.com/clinical-characteristics-treatment-outcome-and-associated-factors-of-e-peer-reviewed-fulltext-article-PHMT |
| _version_ | 1797643718354796544 |
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| author | Nasir M Abebaw E Ahmed M Ketema DB |
| author_facet | Nasir M Abebaw E Ahmed M Ketema DB |
| author_sort | Nasir M |
| collection | DOAJ |
| description | Mohammed Nasir,1 Ermias Abebaw,2 Muluken Ahmed,3 Daniel Bekele Ketema4 1Pediatrics Department, Hawassa University, Hawassa, Ethiopia; 2Pediatrics Department, ALERT Comprehensive Specialized Hospital, Addis Ababa, Ethiopia; 3Pediatrics Department, Arba Minch University, Arba Minch, Ethiopia; 4Public Health Department, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Mohammed Nasir, Pediatrics Department, Hawassa University, Hawassa, Ethiopia, Tel +251-911739081, Email mn2572338@gmail.comBackground: Epilepsy is an important cause of neurological morbidity in children and adolescents. Clinical parameters are the main diagnostic tools, especially in developing countries. Although cost-effective treatments for epilepsy are available, studies have shown that uncontrolled seizures can occur in many patients.Objective: To assess clinical characteristics, treatment outcomes, and associated factors for controlled epilepsy among children with epilepsy who underwent follow-up at the Debre Markos Comprehensive Specialized Hospital, North-west Ethiopia from October 28, 2020, to April 28, 2021.Methods: An institutional-based retrospective cohort study was conducted from October 28, 2020, to April 28, 2021. A total of 385 participants who fulfilled the inclusion criteria were included in the study. A pretested, structured, interviewer-administered questionnaire with a chart review was used to collect data. The data were entered into the Epi-data software version 4.4.2.1 and then exported to the Stata version 14 statistical package for analysis. Descriptive statistics were used to describe the sociodemographic and clinical characteristics, treatment profiles, and treatment outcomes of patients with epilepsy. Bivariate and multivariate analyses were used to identify factors associated with treatment outcomes.Results: The most frequent type of seizure among the 385 respondents was Generalized-tonic-clonic seizures (88.1%). The proximate cause of seizures was identified in 15% of patients, of whom 45 had a perinatal history (8.8%), head injury (3.6%), and CNS infection (2.3%). One-third of patients had poor seizure control. Caregiver relationship (father AOR=0.58; 95th CI:0.35,0.97) and poor adherence (AOR=2.97; 95th CI:1.82, 4.86) were significantly associated with treatment outcome.Conclusion: One-third of children with epilepsy have poor seizure control. Poor adherence to treatment is implicated in poor control. Counseling caregivers on proper treatment and adherence to anti-epileptic medication is recommended to improve treatment outcome in children.Keywords: children, epilepsy, seizure, treatment outcome, Ethiopia |
| first_indexed | 2024-03-11T14:20:06Z |
| format | Article |
| id | doaj.art-1e1bdc61cd07466fb9d1476c15b80196 |
| institution | Directory Open Access Journal |
| issn | 1179-9927 |
| language | English |
| last_indexed | 2024-03-11T14:20:06Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Pediatric Health, Medicine and Therapeutics |
| spelling | doaj.art-1e1bdc61cd07466fb9d1476c15b801962023-10-31T17:33:54ZengDove Medical PressPediatric Health, Medicine and Therapeutics1179-99272023-10-01Volume 1438540487757Clinical Characteristics, Treatment Outcome and Associated Factors of Epilepsy Among Children at Hospitals of North-West EthiopiaNasir MAbebaw EAhmed MKetema DBMohammed Nasir,1 Ermias Abebaw,2 Muluken Ahmed,3 Daniel Bekele Ketema4 1Pediatrics Department, Hawassa University, Hawassa, Ethiopia; 2Pediatrics Department, ALERT Comprehensive Specialized Hospital, Addis Ababa, Ethiopia; 3Pediatrics Department, Arba Minch University, Arba Minch, Ethiopia; 4Public Health Department, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Mohammed Nasir, Pediatrics Department, Hawassa University, Hawassa, Ethiopia, Tel +251-911739081, Email mn2572338@gmail.comBackground: Epilepsy is an important cause of neurological morbidity in children and adolescents. Clinical parameters are the main diagnostic tools, especially in developing countries. Although cost-effective treatments for epilepsy are available, studies have shown that uncontrolled seizures can occur in many patients.Objective: To assess clinical characteristics, treatment outcomes, and associated factors for controlled epilepsy among children with epilepsy who underwent follow-up at the Debre Markos Comprehensive Specialized Hospital, North-west Ethiopia from October 28, 2020, to April 28, 2021.Methods: An institutional-based retrospective cohort study was conducted from October 28, 2020, to April 28, 2021. A total of 385 participants who fulfilled the inclusion criteria were included in the study. A pretested, structured, interviewer-administered questionnaire with a chart review was used to collect data. The data were entered into the Epi-data software version 4.4.2.1 and then exported to the Stata version 14 statistical package for analysis. Descriptive statistics were used to describe the sociodemographic and clinical characteristics, treatment profiles, and treatment outcomes of patients with epilepsy. Bivariate and multivariate analyses were used to identify factors associated with treatment outcomes.Results: The most frequent type of seizure among the 385 respondents was Generalized-tonic-clonic seizures (88.1%). The proximate cause of seizures was identified in 15% of patients, of whom 45 had a perinatal history (8.8%), head injury (3.6%), and CNS infection (2.3%). One-third of patients had poor seizure control. Caregiver relationship (father AOR=0.58; 95th CI:0.35,0.97) and poor adherence (AOR=2.97; 95th CI:1.82, 4.86) were significantly associated with treatment outcome.Conclusion: One-third of children with epilepsy have poor seizure control. Poor adherence to treatment is implicated in poor control. Counseling caregivers on proper treatment and adherence to anti-epileptic medication is recommended to improve treatment outcome in children.Keywords: children, epilepsy, seizure, treatment outcome, Ethiopiahttps://www.dovepress.com/clinical-characteristics-treatment-outcome-and-associated-factors-of-e-peer-reviewed-fulltext-article-PHMTchildrenepilepsyseizuretreatment outcomeethiopia |
| spellingShingle | Nasir M Abebaw E Ahmed M Ketema DB Clinical Characteristics, Treatment Outcome and Associated Factors of Epilepsy Among Children at Hospitals of North-West Ethiopia Pediatric Health, Medicine and Therapeutics children epilepsy seizure treatment outcome ethiopia |
| title | Clinical Characteristics, Treatment Outcome and Associated Factors of Epilepsy Among Children at Hospitals of North-West Ethiopia |
| title_full | Clinical Characteristics, Treatment Outcome and Associated Factors of Epilepsy Among Children at Hospitals of North-West Ethiopia |
| title_fullStr | Clinical Characteristics, Treatment Outcome and Associated Factors of Epilepsy Among Children at Hospitals of North-West Ethiopia |
| title_full_unstemmed | Clinical Characteristics, Treatment Outcome and Associated Factors of Epilepsy Among Children at Hospitals of North-West Ethiopia |
| title_short | Clinical Characteristics, Treatment Outcome and Associated Factors of Epilepsy Among Children at Hospitals of North-West Ethiopia |
| title_sort | clinical characteristics treatment outcome and associated factors of epilepsy among children at hospitals of north west ethiopia |
| topic | children epilepsy seizure treatment outcome ethiopia |
| url | https://www.dovepress.com/clinical-characteristics-treatment-outcome-and-associated-factors-of-e-peer-reviewed-fulltext-article-PHMT |
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