Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Abstract Background and purpose Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in reduced immune activity, the role of TILs in elderly HNSCC pat...

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Bibliographic Details
Main Authors: Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser, Nils H. Nicolay
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Radiation Oncology
Subjects:
Head-and-neck cancer
Elderly
Geriatric
Immunosenescence
Immune checkpoint
Tumor-infiltrating lymphocytes
Online Access:https://doi.org/10.1186/s13014-022-02153-9

Internet

https://doi.org/10.1186/s13014-022-02153-9

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