The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor
Triggering receptor expressed on myeloid cell-2 (TRE M2) is a transmembrane receptor which is specifically expressed on myeloid cells. To date, TRE M2 has been confirmed as a key factor in many pathologies, such as Alzheimer’s disease, obesity-related metabolic syndrome, fatty liver and atherosclero...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-01-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/The-emerging-role-of-triggering-receptor-expressed-on-myeloid-cell-2-in-malignant-tumor,10,49990,1,1.html |
| _version_ | 1827058468950900736 |
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| author | Yahui Wang Ying Chu Fenghua Cao Zhihong Chen Huaxi Xu Shengjun Wang Jie Ma |
| author_facet | Yahui Wang Ying Chu Fenghua Cao Zhihong Chen Huaxi Xu Shengjun Wang Jie Ma |
| author_sort | Yahui Wang |
| collection | DOAJ |
| description | Triggering receptor expressed on myeloid cell-2 (TRE M2) is a transmembrane receptor which is specifically expressed on myeloid cells. To date, TRE M2 has been confirmed as a key factor in many pathologies, such as Alzheimer’s disease, obesity-related metabolic syndrome, fatty liver and atherosclerosis. However, the role of TRE M2 in tumors remains poorly understood. TRE M2 is highly expressed in more than 200 primary and metastatic tumors, a feature that makes TRE M2 a potential clinical target for tumor immunotherapy. The tumor microenvironment (TME) is the “soil” which tumors survive on and exhibits immunosuppressive characteristics. During the development of a tumor, TME will secrete
various chemotactic factors to recruit myeloid cells. It is clear now that cancer progression and metastasis depend on the interactions between cancer cells and myeloid cell infiltration in TME. As an important receptor involved in inflammatory suppression signaling pathways, TRE M2 may play an important role in immune escape by the tumor. Recently, several studies have illustrated that TRE M2 expressed on tumor infiltrated myeloid cells acts as a crucial regulator of the antitumor immune response. In this review, we systematically summarize recent publications about the latest advances in knowledge of TRE M2 in cancer, especially focusing on its role in tumor associated myeloid cells and tumor immunotherapy. |
| first_indexed | 2024-04-09T16:52:00Z |
| format | Article |
| id | doaj.art-1e1ddb2b37e34fb781b350a1572be788 |
| institution | Directory Open Access Journal |
| issn | 1426-3912 1644-4124 |
| language | English |
| last_indexed | 2025-02-18T18:24:25Z |
| publishDate | 2023-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj.art-1e1ddb2b37e34fb781b350a1572be7882024-10-22T08:02:30ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242023-01-0147437338110.5114/ceji.2022.12438749990The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumorYahui WangYing ChuFenghua CaoZhihong ChenHuaxi XuShengjun WangJie MaTriggering receptor expressed on myeloid cell-2 (TRE M2) is a transmembrane receptor which is specifically expressed on myeloid cells. To date, TRE M2 has been confirmed as a key factor in many pathologies, such as Alzheimer’s disease, obesity-related metabolic syndrome, fatty liver and atherosclerosis. However, the role of TRE M2 in tumors remains poorly understood. TRE M2 is highly expressed in more than 200 primary and metastatic tumors, a feature that makes TRE M2 a potential clinical target for tumor immunotherapy. The tumor microenvironment (TME) is the “soil” which tumors survive on and exhibits immunosuppressive characteristics. During the development of a tumor, TME will secrete various chemotactic factors to recruit myeloid cells. It is clear now that cancer progression and metastasis depend on the interactions between cancer cells and myeloid cell infiltration in TME. As an important receptor involved in inflammatory suppression signaling pathways, TRE M2 may play an important role in immune escape by the tumor. Recently, several studies have illustrated that TRE M2 expressed on tumor infiltrated myeloid cells acts as a crucial regulator of the antitumor immune response. In this review, we systematically summarize recent publications about the latest advances in knowledge of TRE M2 in cancer, especially focusing on its role in tumor associated myeloid cells and tumor immunotherapy.https://www.termedia.pl/The-emerging-role-of-triggering-receptor-expressed-on-myeloid-cell-2-in-malignant-tumor,10,49990,1,1.htmltriggering receptor expressed on myeloid cell-2 malignant tumor tumor immunotherapy tumor infiltrating myeloid cells |
| spellingShingle | Yahui Wang Ying Chu Fenghua Cao Zhihong Chen Huaxi Xu Shengjun Wang Jie Ma The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor Central European Journal of Immunology triggering receptor expressed on myeloid cell-2 malignant tumor tumor immunotherapy tumor infiltrating myeloid cells |
| title | The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor |
| title_full | The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor |
| title_fullStr | The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor |
| title_full_unstemmed | The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor |
| title_short | The emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor |
| title_sort | emerging role of triggering receptor expressed on myeloid cell 2 in malignant tumor |
| topic | triggering receptor expressed on myeloid cell-2 malignant tumor tumor immunotherapy tumor infiltrating myeloid cells |
| url | https://www.termedia.pl/The-emerging-role-of-triggering-receptor-expressed-on-myeloid-cell-2-in-malignant-tumor,10,49990,1,1.html |
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