Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus
Host’s innate immunity is the front-line defense against viral infections, but some viruses have evolved multiple strategies for evasion of antiviral innate immunity. The porcine enteric coronaviruses (PECs) consist of porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.845137/full |
| _version_ | 1819278593784545280 |
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| author | Kunli Zhang Kunli Zhang Sen Lin Jianhao Li Shoulong Deng Jianfeng Zhang Jianfeng Zhang Sutian Wang |
| author_facet | Kunli Zhang Kunli Zhang Sen Lin Jianhao Li Shoulong Deng Jianfeng Zhang Jianfeng Zhang Sutian Wang |
| author_sort | Kunli Zhang |
| collection | DOAJ |
| description | Host’s innate immunity is the front-line defense against viral infections, but some viruses have evolved multiple strategies for evasion of antiviral innate immunity. The porcine enteric coronaviruses (PECs) consist of porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis coronavirus (TGEV), and swine acute diarrhea syndrome-coronavirus (SADS-CoV), which cause lethal diarrhea in neonatal pigs and threaten the swine industry worldwide. PECs interact with host cells to inhibit and evade innate antiviral immune responses like other coronaviruses. Moreover, the immune escape of porcine enteric coronaviruses is the key pathogenic mechanism causing infection. Here, we review the most recent advances in the interactions between viral and host’s factors, focusing on the mechanisms by which viral components antagonize interferon (IFN)-mediated innate antiviral immune responses, trying to shed light on new targets and strategies effective for controlling and eliminating porcine enteric coronaviruses. |
| first_indexed | 2024-12-24T00:14:29Z |
| format | Article |
| id | doaj.art-1e203ee95bda4069b0d7e70284b86811 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-24T00:14:29Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-1e203ee95bda4069b0d7e70284b868112022-12-21T17:24:47ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-02-011310.3389/fmicb.2022.845137845137Modulation of Innate Antiviral Immune Response by Porcine Enteric CoronavirusKunli Zhang0Kunli Zhang1Sen Lin2Jianhao Li3Shoulong Deng4Jianfeng Zhang5Jianfeng Zhang6Sutian Wang7State Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaInstitute of Animal Health, Guangdong Academy of Agricultural Sciences, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaSericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaInstitute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, ChinaInstitute of Animal Health, Guangdong Academy of Agricultural Sciences, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaMaoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaHost’s innate immunity is the front-line defense against viral infections, but some viruses have evolved multiple strategies for evasion of antiviral innate immunity. The porcine enteric coronaviruses (PECs) consist of porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis coronavirus (TGEV), and swine acute diarrhea syndrome-coronavirus (SADS-CoV), which cause lethal diarrhea in neonatal pigs and threaten the swine industry worldwide. PECs interact with host cells to inhibit and evade innate antiviral immune responses like other coronaviruses. Moreover, the immune escape of porcine enteric coronaviruses is the key pathogenic mechanism causing infection. Here, we review the most recent advances in the interactions between viral and host’s factors, focusing on the mechanisms by which viral components antagonize interferon (IFN)-mediated innate antiviral immune responses, trying to shed light on new targets and strategies effective for controlling and eliminating porcine enteric coronaviruses.https://www.frontiersin.org/articles/10.3389/fmicb.2022.845137/fullporcine enteric coronavirusesinnate immunity responseimmune evasionPEDVPDCoVTGEV |
| spellingShingle | Kunli Zhang Kunli Zhang Sen Lin Jianhao Li Shoulong Deng Jianfeng Zhang Jianfeng Zhang Sutian Wang Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus Frontiers in Microbiology porcine enteric coronaviruses innate immunity response immune evasion PEDV PDCoV TGEV |
| title | Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus |
| title_full | Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus |
| title_fullStr | Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus |
| title_full_unstemmed | Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus |
| title_short | Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus |
| title_sort | modulation of innate antiviral immune response by porcine enteric coronavirus |
| topic | porcine enteric coronaviruses innate immunity response immune evasion PEDV PDCoV TGEV |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.845137/full |
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