Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats
Abstract Background Renal denervation (RDN) can reduce ventricular arrhythmia after acute myocardial infarction (AMI), but the mechanism is not clear. The purpose of this study is to study its mechanism. Methods Thirty-two Sprague–Dawley rats were divided into four groups: control group, AMI group,...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02980-4 |
| _version_ | 1798005329238163456 |
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| author | Jian Ye Rongxue Xiao Xu Wang Ruiqing He Zongjun Liu Junqing Gao |
| author_facet | Jian Ye Rongxue Xiao Xu Wang Ruiqing He Zongjun Liu Junqing Gao |
| author_sort | Jian Ye |
| collection | DOAJ |
| description | Abstract Background Renal denervation (RDN) can reduce ventricular arrhythmia after acute myocardial infarction (AMI), but the mechanism is not clear. The purpose of this study is to study its mechanism. Methods Thirty-two Sprague–Dawley rats were divided into four groups: control group, AMI group, RDN-1d + AMI group, RDN-2w + AMI group. The AMI model was established 1 day after RDN in the RDN-1d + AMI group and 2 weeks after RDN in the RDN-2w + AMI group. At the same time, 8 normal rats were subjected to AMI modelling (the AMI group). The control group consisted of 8 rats without RDN intervention or AMI modelling. Results The study confirmed that RDN can reduce the occurrence of ventricular tachycardia in AMI rats, reduce renal sympathetic nerve discharge, and inhibit the activity of local sympathetic nerves and cell growth factor (NGF) protein expression in the heart after AMI. In addition, RDN decreased the expression of norepinephrine (NE) and glutamate in the hypothalamus,and NE in cerebrospinal fluid, and increased the expression level of γ aminobutyric acid (GABA) in the hypothalamus after AMI. Conclusion RDN can effectively reduce the occurrence of ventricular arrhythmia after AMI, and its main mechanism may be via the inhibition of central sympathetic nerve discharge. |
| first_indexed | 2024-04-11T12:37:25Z |
| format | Article |
| id | doaj.art-1e20a27d4a5140e2a8425df8e278f09b |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-11T12:37:25Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-1e20a27d4a5140e2a8425df8e278f09b2022-12-22T04:23:35ZengBMCBMC Cardiovascular Disorders1471-22612022-12-0122111010.1186/s12872-022-02980-4Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in ratsJian Ye0Rongxue Xiao1Xu Wang2Ruiqing He3Zongjun Liu4Junqing Gao5Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineShanghai Putuo Central School of Clinical Medicine, Anhui Medical UniversityDepartment of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineShanghai Putuo Central School of Clinical Medicine, Anhui Medical UniversityDepartment of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese MedicineAbstract Background Renal denervation (RDN) can reduce ventricular arrhythmia after acute myocardial infarction (AMI), but the mechanism is not clear. The purpose of this study is to study its mechanism. Methods Thirty-two Sprague–Dawley rats were divided into four groups: control group, AMI group, RDN-1d + AMI group, RDN-2w + AMI group. The AMI model was established 1 day after RDN in the RDN-1d + AMI group and 2 weeks after RDN in the RDN-2w + AMI group. At the same time, 8 normal rats were subjected to AMI modelling (the AMI group). The control group consisted of 8 rats without RDN intervention or AMI modelling. Results The study confirmed that RDN can reduce the occurrence of ventricular tachycardia in AMI rats, reduce renal sympathetic nerve discharge, and inhibit the activity of local sympathetic nerves and cell growth factor (NGF) protein expression in the heart after AMI. In addition, RDN decreased the expression of norepinephrine (NE) and glutamate in the hypothalamus,and NE in cerebrospinal fluid, and increased the expression level of γ aminobutyric acid (GABA) in the hypothalamus after AMI. Conclusion RDN can effectively reduce the occurrence of ventricular arrhythmia after AMI, and its main mechanism may be via the inhibition of central sympathetic nerve discharge.https://doi.org/10.1186/s12872-022-02980-4Renal denervationAcute myocardial infarctionVentricular arrhythmiaCentral nervous systemSympathetic nerve |
| spellingShingle | Jian Ye Rongxue Xiao Xu Wang Ruiqing He Zongjun Liu Junqing Gao Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats BMC Cardiovascular Disorders Renal denervation Acute myocardial infarction Ventricular arrhythmia Central nervous system Sympathetic nerve |
| title | Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats |
| title_full | Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats |
| title_fullStr | Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats |
| title_full_unstemmed | Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats |
| title_short | Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats |
| title_sort | effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats |
| topic | Renal denervation Acute myocardial infarction Ventricular arrhythmia Central nervous system Sympathetic nerve |
| url | https://doi.org/10.1186/s12872-022-02980-4 |
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