MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons
Information from Magnetic Resonance Imaging (MRI) is useful for diagnosis and treatment management of human neurological patients. MRI monitoring might also prove useful for non-human animals involved in neuroscience research provided that MRI is available and feasible and that there are no MRI cont...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921000550 |
| _version_ | 1818743226057621504 |
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| author | Fabien Balezeau Jennifer Nacef Yukiko Kikuchi Felix Schneider Francesca Rocchi Ross S. Muers Rocio Fernandez-Palacios O'Connor Christoph Blau Benjamin Wilson Richard C. Saunders Matthew Howard, III Alexander Thiele Timothy D. Griffiths Christopher I. Petkov Kathy Murphy |
| author_facet | Fabien Balezeau Jennifer Nacef Yukiko Kikuchi Felix Schneider Francesca Rocchi Ross S. Muers Rocio Fernandez-Palacios O'Connor Christoph Blau Benjamin Wilson Richard C. Saunders Matthew Howard, III Alexander Thiele Timothy D. Griffiths Christopher I. Petkov Kathy Murphy |
| author_sort | Fabien Balezeau |
| collection | DOAJ |
| description | Information from Magnetic Resonance Imaging (MRI) is useful for diagnosis and treatment management of human neurological patients. MRI monitoring might also prove useful for non-human animals involved in neuroscience research provided that MRI is available and feasible and that there are no MRI contra-indications precluding scanning. However, MRI monitoring is not established in macaques and a resource is urgently needed that could grow with scientific community contributions. Here we show the utility and potential benefits of MRI-based monitoring in a few diverse cases with macaque monkeys. We also establish a PRIMatE MRI Monitoring (PRIME-MRM) resource within the PRIMatE Data Exchange (PRIME-DE) and quantitatively compare the cases to normative information drawn from MRI data from typical macaques in PRIME-DE. In the cases, the monkeys presented with no or mild/moderate clinical signs, were well otherwise and MRI scanning did not present a significant increase in welfare impact. Therefore, they were identified as suitable candidates for clinical investigation, MRI-based monitoring and treatment. For each case, we show MRI quantification of internal controls in relation to treatment steps and comparisons with normative data in typical monkeys drawn from PRIME-DE. We found that MRI assists in precise and early diagnosis of cerebral events and can be useful for visualising, treating and quantifying treatment response. The scientific community could now grow the PRIME-MRM resource with other cases and larger samples to further assess and increase the evidence base on the benefits of MRI monitoring of primates, complementing the animals’ clinical monitoring and treatment regime. |
| first_indexed | 2024-12-18T02:25:02Z |
| format | Article |
| id | doaj.art-1e213b9205904dc6b725c67f937bed3e |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-18T02:25:02Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-1e213b9205904dc6b725c67f937bed3e2022-12-21T21:24:03ZengElsevierNeuroImage1095-95722021-04-01230117778MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisonsFabien Balezeau0Jennifer Nacef1Yukiko Kikuchi2Felix Schneider3Francesca Rocchi4Ross S. Muers5Rocio Fernandez-Palacios O'Connor6Christoph Blau7Benjamin Wilson8Richard C. Saunders9Matthew Howard, III10Alexander Thiele11Timothy D. Griffiths12Christopher I. Petkov13Kathy Murphy14Biosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomBiosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomBiosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomBiosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomBiosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomBiosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomComparative Biology Centre, Newcastle University, Newcastle upon Tyne, United KingdomComparative Biology Centre, Newcastle University, Newcastle upon Tyne, United KingdomBiosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomLaboratory of Neuropsychology, National Institutes of Health (NIMH), Bethesda, MD, United StatesDepartment of Neurosurgery, University of Iowa, Iowa City, IA, United StatesBiosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomBiosciences Institute, Newcastle University, Newcastle upon Tyne, United KingdomBiosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Corresponding authors.Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, United Kingdom; Corresponding authors.Information from Magnetic Resonance Imaging (MRI) is useful for diagnosis and treatment management of human neurological patients. MRI monitoring might also prove useful for non-human animals involved in neuroscience research provided that MRI is available and feasible and that there are no MRI contra-indications precluding scanning. However, MRI monitoring is not established in macaques and a resource is urgently needed that could grow with scientific community contributions. Here we show the utility and potential benefits of MRI-based monitoring in a few diverse cases with macaque monkeys. We also establish a PRIMatE MRI Monitoring (PRIME-MRM) resource within the PRIMatE Data Exchange (PRIME-DE) and quantitatively compare the cases to normative information drawn from MRI data from typical macaques in PRIME-DE. In the cases, the monkeys presented with no or mild/moderate clinical signs, were well otherwise and MRI scanning did not present a significant increase in welfare impact. Therefore, they were identified as suitable candidates for clinical investigation, MRI-based monitoring and treatment. For each case, we show MRI quantification of internal controls in relation to treatment steps and comparisons with normative data in typical monkeys drawn from PRIME-DE. We found that MRI assists in precise and early diagnosis of cerebral events and can be useful for visualising, treating and quantifying treatment response. The scientific community could now grow the PRIME-MRM resource with other cases and larger samples to further assess and increase the evidence base on the benefits of MRI monitoring of primates, complementing the animals’ clinical monitoring and treatment regime.http://www.sciencedirect.com/science/article/pii/S1053811921000550Magnetic resonance imagingPrimateWelfareNeurologyMonitoringDiagnosis |
| spellingShingle | Fabien Balezeau Jennifer Nacef Yukiko Kikuchi Felix Schneider Francesca Rocchi Ross S. Muers Rocio Fernandez-Palacios O'Connor Christoph Blau Benjamin Wilson Richard C. Saunders Matthew Howard, III Alexander Thiele Timothy D. Griffiths Christopher I. Petkov Kathy Murphy MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons NeuroImage Magnetic resonance imaging Primate Welfare Neurology Monitoring Diagnosis |
| title | MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons |
| title_full | MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons |
| title_fullStr | MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons |
| title_full_unstemmed | MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons |
| title_short | MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons |
| title_sort | mri monitoring of macaque monkeys in neuroscience case studies resource and normative data comparisons |
| topic | Magnetic resonance imaging Primate Welfare Neurology Monitoring Diagnosis |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921000550 |
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