Rotavirus infection in Saudi Arabia
<b>Background: </b>Human rotavirus, an important causative agent of severe gastroenteritis in infants and young children worldwide, leads to high morbidity in both developing and developed countries, including Saudi Arabia, and high mortality in developing countries. Effective control de...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2006-01-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2006;volume=26;issue=3;spage=184;epage=191;aulast=Kheyami |
| _version_ | 1811273956750000128 |
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| author | Kheyami Ali Cunliffe Nigel Hart C |
| author_facet | Kheyami Ali Cunliffe Nigel Hart C |
| author_sort | Kheyami Ali |
| collection | DOAJ |
| description | <b>Background: </b>Human rotavirus, an important causative agent of severe gastroenteritis in infants and young children worldwide, leads to high morbidity in both developing and developed countries, including Saudi Arabia, and high mortality in developing countries. Effective control depends upon an accurate understanding of disease burden and the relative importance of circulating serotypes. <b>Methods: </b>We examined the epidemiology and disease burden of rotavirus in Saudi Arabia through a review of 22 published studies of rotavirus and the aetiology of diarrhoea carried out from 1982 to 2003. <b>Results: </b>The prevalence of rotavirus infection ranged between 10% to 46% with a median of 30%. Most cases were among children less than 2 years of age, and particularly in the first year of life. There were significant differences in seasonality within Saudi Arabia, with increased infection during winter in some cities and during summer in others. G1 was the predominant serotype followed by G4, G3 and G2, in 4 studies where strains had been G-typed. The prevalence of nontypeable strains ranged from 11.0% to 31.3%. No data were available on P types. Results of electropherotyping in 4 studies revealed that the long electropherotype was predominant. <b>Conclusion: </b>Rotavirus is an important cause of severe diarrhoea in Saudi children. However, the available data on rotavirus strains in circulation are limited and there is an urgent need for up-to-date and comprehensive studies to evaluate rotavirus strains in circulation and identify unusual types that could be incorporated into future vaccines. |
| first_indexed | 2024-04-12T23:09:03Z |
| format | Article |
| id | doaj.art-1e244f79a6014b2185b2f5eb8c1146a3 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-04-12T23:09:03Z |
| publishDate | 2006-01-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-1e244f79a6014b2185b2f5eb8c1146a32022-12-22T03:12:50ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662006-01-01263184191Rotavirus infection in Saudi ArabiaKheyami AliCunliffe NigelHart C<b>Background: </b>Human rotavirus, an important causative agent of severe gastroenteritis in infants and young children worldwide, leads to high morbidity in both developing and developed countries, including Saudi Arabia, and high mortality in developing countries. Effective control depends upon an accurate understanding of disease burden and the relative importance of circulating serotypes. <b>Methods: </b>We examined the epidemiology and disease burden of rotavirus in Saudi Arabia through a review of 22 published studies of rotavirus and the aetiology of diarrhoea carried out from 1982 to 2003. <b>Results: </b>The prevalence of rotavirus infection ranged between 10% to 46% with a median of 30%. Most cases were among children less than 2 years of age, and particularly in the first year of life. There were significant differences in seasonality within Saudi Arabia, with increased infection during winter in some cities and during summer in others. G1 was the predominant serotype followed by G4, G3 and G2, in 4 studies where strains had been G-typed. The prevalence of nontypeable strains ranged from 11.0% to 31.3%. No data were available on P types. Results of electropherotyping in 4 studies revealed that the long electropherotype was predominant. <b>Conclusion: </b>Rotavirus is an important cause of severe diarrhoea in Saudi children. However, the available data on rotavirus strains in circulation are limited and there is an urgent need for up-to-date and comprehensive studies to evaluate rotavirus strains in circulation and identify unusual types that could be incorporated into future vaccines.http://www.saudiannals.net/article.asp?issn=0256-4947;year=2006;volume=26;issue=3;spage=184;epage=191;aulast=Kheyami |
| spellingShingle | Kheyami Ali Cunliffe Nigel Hart C Rotavirus infection in Saudi Arabia Annals of Saudi Medicine |
| title | Rotavirus infection in Saudi Arabia |
| title_full | Rotavirus infection in Saudi Arabia |
| title_fullStr | Rotavirus infection in Saudi Arabia |
| title_full_unstemmed | Rotavirus infection in Saudi Arabia |
| title_short | Rotavirus infection in Saudi Arabia |
| title_sort | rotavirus infection in saudi arabia |
| url | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2006;volume=26;issue=3;spage=184;epage=191;aulast=Kheyami |
| work_keys_str_mv | AT kheyamiali rotavirusinfectioninsaudiarabia AT cunliffenigel rotavirusinfectioninsaudiarabia AT hartc rotavirusinfectioninsaudiarabia |