Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease Eradication
The mosquito-borne lymphatic filariasis (LF) is a parasitic, neglected tropical disease that imposes an unbearable human scourge. Despite the unprecedented efforts in mass drug administration (MDA) and morbidity management, achieving the global LF elimination slated for the year 2020 has been thwart...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | http://www.mdpi.com/2414-6366/3/1/4 |
| _version_ | 1811186468139302912 |
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| author | Damilare O. Famakinde |
| author_facet | Damilare O. Famakinde |
| author_sort | Damilare O. Famakinde |
| collection | DOAJ |
| description | The mosquito-borne lymphatic filariasis (LF) is a parasitic, neglected tropical disease that imposes an unbearable human scourge. Despite the unprecedented efforts in mass drug administration (MDA) and morbidity management, achieving the global LF elimination slated for the year 2020 has been thwarted by limited MDA coverage and ineffectiveness in the chemotherapeutic intervention. Moreover, successful and sustainable elimination of mosquito-vectored diseases is often encumbered by reintroduction and resurgence emanating from human residual or new infections being widely disseminated by the vectors even when chemotherapy proves effective, but especially in the absence of effective vaccines. This created impetus for strengthening the current defective mosquito control approach, and profound research in vector–pathogen systems and vector biology has been pushing the boundaries of ideas towards developing refined vector-harnessed control strategies. Eventual implementation of these emerging concepts will offer a synergistic approach that will not only accelerate LF elimination, but also augurs well for its future eradication. This brief review focuses on advances in mosquito–filaria research and considers the emerging prospects for future eradication of LF. |
| first_indexed | 2024-04-11T13:45:55Z |
| format | Article |
| id | doaj.art-1e2730a9050847aa8b592b13c9a45526 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-04-11T13:45:55Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-1e2730a9050847aa8b592b13c9a455262022-12-22T04:21:02ZengMDPI AGTropical Medicine and Infectious Disease2414-63662018-01-0131410.3390/tropicalmed3010004tropicalmed3010004Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease EradicationDamilare O. Famakinde0Department of Medical Microbiology and Parasitology, College of Medicine of the University of Lagos, Idi-Araba, Lagos 100254, NigeriaThe mosquito-borne lymphatic filariasis (LF) is a parasitic, neglected tropical disease that imposes an unbearable human scourge. Despite the unprecedented efforts in mass drug administration (MDA) and morbidity management, achieving the global LF elimination slated for the year 2020 has been thwarted by limited MDA coverage and ineffectiveness in the chemotherapeutic intervention. Moreover, successful and sustainable elimination of mosquito-vectored diseases is often encumbered by reintroduction and resurgence emanating from human residual or new infections being widely disseminated by the vectors even when chemotherapy proves effective, but especially in the absence of effective vaccines. This created impetus for strengthening the current defective mosquito control approach, and profound research in vector–pathogen systems and vector biology has been pushing the boundaries of ideas towards developing refined vector-harnessed control strategies. Eventual implementation of these emerging concepts will offer a synergistic approach that will not only accelerate LF elimination, but also augurs well for its future eradication. This brief review focuses on advances in mosquito–filaria research and considers the emerging prospects for future eradication of LF.http://www.mdpi.com/2414-6366/3/1/4mosquitoesfilarial parasitesvector–parasite systemlymphatic filariasiseradication |
| spellingShingle | Damilare O. Famakinde Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease Eradication Tropical Medicine and Infectious Disease mosquitoes filarial parasites vector–parasite system lymphatic filariasis eradication |
| title | Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease Eradication |
| title_full | Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease Eradication |
| title_fullStr | Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease Eradication |
| title_full_unstemmed | Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease Eradication |
| title_short | Mosquitoes and the Lymphatic Filarial Parasites: Research Trends and Budding Roadmaps to Future Disease Eradication |
| title_sort | mosquitoes and the lymphatic filarial parasites research trends and budding roadmaps to future disease eradication |
| topic | mosquitoes filarial parasites vector–parasite system lymphatic filariasis eradication |
| url | http://www.mdpi.com/2414-6366/3/1/4 |
| work_keys_str_mv | AT damilareofamakinde mosquitoesandthelymphaticfilarialparasitesresearchtrendsandbuddingroadmapstofuturediseaseeradication |